Avdelidis D, Spyraki C
Brain Res Bull. 1986 Jan;16(1):25-32. doi: 10.1016/0361-9230(86)90008-0.
Amphetamine hyperactivity, apomorphine stereotypy and haloperidol catalepsy were studied in rats following selective damage to cell bodies within the globus pallidus (GP). Ibotenic acid-induced bilateral lesions of GP attenuated the spontaneous locomotion of rats, but they did not influence the locomotor response to amphetamine. Apomorphine-induced gnawing and licking but not sniffing were attenuated in rats with GP lesions. The effect of haloperidol on catalepsy was enhanced following the GP lesion. It is concluded that the normal expression of some dopamine-related functions depends to a great degree on the integrity of cells within the GP region.
在大鼠苍白球（GP）内细胞体受到选择性损伤后，研究了苯丙胺所致多动、阿扑吗啡所致刻板行为以及氟哌啶醇所致僵住症。鹅膏蕈氨酸诱导的GP双侧损伤减弱了大鼠的自发运动，但不影响对苯丙胺的运动反应。在GP损伤的大鼠中，阿扑吗啡诱导的啃咬和舔舐行为减弱，但嗅探行为未受影响。GP损伤后，氟哌啶醇对僵住症的作用增强。结论是，一些多巴胺相关功能的正常表达在很大程度上依赖于GP区域内细胞的完整性。
