迷走神经干切断术对大鼠胰腺的营养作用

Trophic effect of truncal vagotomy on the rat pancreas.

作者信息

Koop H, Schwarting H, Trautmann M, Börger H W, Lankisch P G, Arnold R, Creutzfeldt W

出版信息

Digestion. 1986;33(4):198-205. doi: 10.1159/000199295.

DOI:10.1159/000199295

Abstract

The trophic effect of truncal vagotomy was studied in rats. Three months after vagotomy and pyloroplasty pancreatic weight was significantly increased by 40% (p less than 0.001). Gastric stasis and consecutive distension of the stomach was observed in the majority of vagotomized animals despite pyloroplasty; the trophic effect of vagotomy on the pancreas was most pronounced in animals with severe stomach distension. Basal gastrin levels were increased after truncal vagotomy but did not correlate to gastric stasis and to the hypertrophy and hyperplasia of the exocrine pancreas. Basal pancreatic polypeptide hexapeptide levels were not altered after vagotomy. Morphometric studies on the endocrine pancreatic tissue showed that the relative volume density decreased due to the increase in exocrine tissue. However, the total islet cell mass remained constant. It is concluded that chronic truncal vagotomy has a trophic effect on the exocrine but not on the endocrine pancreas; additional factors besides gastrin seem to be responsible for this.

摘要

在大鼠中研究了迷走神经干切断术的营养作用。迷走神经切断术和幽门成形术三个月后，胰腺重量显著增加了40%（p<0.001）。尽管进行了幽门成形术，但在大多数迷走神经切断的动物中仍观察到胃潴留和胃的持续扩张；迷走神经切断术对胰腺的营养作用在胃严重扩张的动物中最为明显。迷走神经干切断术后基础胃泌素水平升高，但与胃潴留以及外分泌胰腺的肥大和增生无关。迷走神经切断术后基础胰多肽六肽水平未改变。对内分泌胰腺组织的形态计量学研究表明，由于外分泌组织的增加，相对体积密度降低。然而，胰岛细胞的总体积保持不变。得出的结论是，慢性迷走神经干切断术对外分泌胰腺有营养作用，但对内分泌胰腺没有；除胃泌素外的其他因素似乎对此负责。