Heeman Wido, Vonk Jasper, Ntziachristos Vasilis, Pogue Brian W, Dierckx Rudi A J O, Kruijff Schelto, van Dam Gooitzen M
University of Groningen, Faculty Campus Fryslân, Leeuwarden, The Netherlands.
Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
J Nucl Med. 2022 May;63(5):640-645. doi: 10.2967/jnumed.121.262975. Epub 2022 Feb 10.
Fluorescence imaging is an emerging imaging technique that has shown many benefits for clinical care. Currently, the field is in rapid clinical translation, and an unprecedented number of clinical trials are performed. Clinicians are inundated with numerous opportunities and combinations of different imaging modalities. To streamline this process, a multidisciplinary approach is needed with drug discovery, software and systems engineering, and translational medicine. Here, we discuss the main constituents of a uniform fluorescence imaging protocol to match the clinical need and ensure consistent study designs and reliable data collection in clinical trials. In an era in which the potential of fluorescence imaging has become evident, consistent conduct of studies, data analysis, and data interpretation is essential for implementation into the standard of care.
荧光成像作为一种新兴的成像技术，已在临床护理中展现出诸多优势。目前，该领域正迅速向临床转化，开展的临床试验数量空前。临床医生面临着众多不同成像模式的机会和组合。为简化这一过程，需要药物研发、软件与系统工程以及转化医学等多学科方法。在此，我们讨论统一荧光成像方案的主要组成部分，以满足临床需求，并确保在临床试验中采用一致的研究设计和可靠的数据收集。在荧光成像的潜力已变得明显的时代，研究、数据分析和数据解释的一致性实施对于纳入护理标准至关重要。
