Millin J A, Golub B M, Foster C S
Invest Ophthalmol Vis Sci. 1986 Apr;27(4):604-7.
Using immunofluorescence techniques, we analyzed the distribution of glycoproteins in normal and keratoconus corneas of humans. Laminin, bullous pemphigoid antigen, fibronectin, and fibrin/fibrinogen were all found in the epithelial basement membrane of normal corneas. Keratoconus corneas produced similar results, except that staining for fibrin/fibrinogen was weak. Fibrin/fibrinogen was absent from normal corneal basement membrane in animal models studied previously. Keratoconus may be the result of the lysis of fibrin or may involve impeded elaboration of fibrin.
我们使用免疫荧光技术分析了人正常角膜和圆锥角膜中糖蛋白的分布情况。层粘连蛋白、大疱性类天疱疮抗原、纤连蛋白以及纤维蛋白/纤维蛋白原在正常角膜的上皮基底膜中均有发现。圆锥角膜产生了类似的结果，只是纤维蛋白/纤维蛋白原的染色较弱。在先前研究的动物模型中，正常角膜基底膜中不存在纤维蛋白/纤维蛋白原。圆锥角膜可能是纤维蛋白溶解的结果，或者可能涉及纤维蛋白形成受阻。
