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耳鸣、突发性感音神经性听力损失和前庭神经炎作为阿斯利康新冠疫苗的并发症

Tinnitus, Sudden Sensorineural Hearing Loss, and Vestibular Neuritis As Complications of the Astra Zeneca COVID-19 Vaccine.

作者信息

Canales Medina Mario, Ramirez Gómez Mariana

机构信息

Otolaryngology - Head and Neck Surgery, Centro Medico Dalinde, Mexico City, MEX.

Medicine, Centro Medico Dalinde, México City, MEX.

出版信息

Cureus. 2022 Jan 3;14(1):e20906. doi: 10.7759/cureus.20906. eCollection 2022 Jan.

Abstract

BACKGROUND

Sudden sensorineural hearing loss is most commonly defined as a sensorineural hearing loss of 30dB or greater over at least three contiguous audiometric frequencies occurring within a 72-hr period. The Astra Zeneca COVID-19 vaccine is suspicious of causing thrombotic complications following its administration, and could theoretically induce hearing loss by damaging the hearing organs through this mechanism, as well as vestibular damage through similar mechanisms.

MATERIAL AND METHODS

We reviewed the files of patients with otological symptoms after exposure to the Astra Zeneca COVID-19 vaccine during the year 2021.

CASE SERIES

We studied a total of six cases with otologic symptoms temporally related to the Astra Zeneca COVID-19 vaccine. We report four cases of patients presenting with hearing loss and tinnitus a few days after the second dose of the Astra Zeneca vaccine, and one case with the same symptoms after the first dose. Four cases were successfully treated with steroids; however, one case presented to the office two months after the onset of symptoms and did not improve with treatment. We also report the first case of vestibular neuritis temporally related to the administration of the first dose of the vaccine, which also had a good outcome after medical treatment.

CONCLUSIONS

Prompt treatment in the present cases was a factor associated with a good prognosis.

摘要

背景

突发性感音神经性听力损失最常被定义为在72小时内至少三个连续听力频率上出现30dB或更大的感音神经性听力损失。阿斯利康新冠疫苗在接种后疑似会引发血栓并发症,理论上可能通过这种机制损害听觉器官从而导致听力损失,以及通过类似机制造成前庭损伤。

材料与方法

我们回顾了2021年接种阿斯利康新冠疫苗后出现耳科症状患者的档案。

病例系列

我们共研究了6例耳科症状与阿斯利康新冠疫苗存在时间关联的病例。我们报告了4例在接种第二剂阿斯利康疫苗几天后出现听力损失和耳鸣的患者,以及1例在接种第一剂后出现相同症状的患者。4例患者通过类固醇治疗成功康复;然而,有1例患者在症状出现两个月后前来就诊,治疗后未见改善。我们还报告了首例前庭神经炎与接种第一剂疫苗存在时间关联的病例,该病例经药物治疗后也取得了良好效果。

结论

在本病例中及时治疗是预后良好的一个相关因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/8810281/5e024233f00d/cureus-0014-00000020906-i01.jpg

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