Mendels J, Krajewski T F, Huffer V, Taylor R J, Secunda S, Schless A, Sebastian J A, Semchyshyn G, Durr M J, Melmed A S
J Clin Psychiatry. 1986 Apr;47(4):170-4.
The effectiveness of trifluoperazine in daily doses of 2 to 6 mg in the short-term treatment of generalized anxiety disorder was evaluated in 415 outpatients in a double-blind, placebo-controlled, multicenter trial. Efficacy and side effects were assessed by a number of psychiatric rating scales for anxiety. All efficacy measurements of anxiety were significantly improved (p less than .001) with trifluoperazine compared to placebo by the end of the study. The side effects profile of trifluoperazine and placebo were similar during the 4-week treatment period.
在一项双盲、安慰剂对照的多中心试验中，对415名门诊患者评估了每日剂量为2至6毫克的三氟拉嗪在广泛性焦虑症短期治疗中的有效性。通过多种焦虑症精神科评定量表评估疗效和副作用。与安慰剂相比，在研究结束时，使用三氟拉嗪治疗的所有焦虑症疗效指标均有显著改善（p<0.001）。在4周的治疗期内，三氟拉嗪和安慰剂的副作用情况相似。
