Ranjbar Mohammad Ali, Jamshidi Maryam
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Undergraduate Student, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran J Otorhinolaryngol. 2022 Jan;34(120):3-8. doi: 10.22038/IJORL.2021.51683.2772.
The overexpression of lysosome-associated membrane protein 1 (LAMP1) has been demonstrated in different types of cancers, such as ovarian carcinoma, esophageal squamous cell carcinoma, breast cancer, and colorectal carcinoma. Nonetheless, the expression of LAMP1 in oral squamous cell carcinoma (OSCC) has not been investigated yet.
This cross-sectional study was conducted on 65 patients with OSCC selected from the Department of Pathology of Shiraz University of Medical Sciences. The control group comprised 55 tissues of normal oral epithelium. The expression of LAMP1 in OSCC tissue samples was assessed using immunohistochemistry (IHC) analysis. The association between LAMP1 and clinicopathological features of patients with OSCC was also evaluated.
The expression of LAMP1 was significantly higher in OSCC tissues, as compared to that in normal tissues (P<0.001). The chi-square analysis indicated that the high LAMP1 expression was correlated with the degree of tumor differentiation and metastasis (P=0.014).
The obtained results pointed to the overexpression of LAMP1 in OSCC, as well as its correlation with tumor grade and metastasis; therefore, LAMP1 might have a role to play in OSCC pathogenesis and could be regarded as an independent prognostic marker in oral squamous cell carcinoma.
溶酶体相关膜蛋白1（LAMP1）的过表达已在不同类型的癌症中得到证实，如卵巢癌、食管鳞状细胞癌、乳腺癌和结直肠癌。然而，LAMP1在口腔鳞状细胞癌（OSCC）中的表达尚未被研究。
本横断面研究对从设拉子医科大学病理科选取的65例OSCC患者进行。对照组包括55个正常口腔上皮组织。采用免疫组织化学（IHC）分析评估OSCC组织样本中LAMP1的表达。还评估了LAMP1与OSCC患者临床病理特征之间的关联。
与正常组织相比，OSCC组织中LAMP1的表达显著更高（P<0.001）。卡方分析表明，LAMP1高表达与肿瘤分化程度和转移相关（P=0.014）。
所得结果表明LAMP1在OSCC中过表达，以及其与肿瘤分级和转移的相关性；因此，LAMP1可能在OSCC发病机制中起作用，并可被视为口腔鳞状细胞癌的独立预后标志物。
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