Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands.
Department of Clinical Genetics, Amsterdam Reproduction & Development research institute, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands.
Lancet Healthy Longev. 2021 May 17;2(6):E327-E339. doi: 10.1016/S2666-7568(21)00087-8.
African populations are experiencing health transitions due to rapid urbanization and international migration. However, the role of biological aging in this emerging burden of cardiometabolic diseases (CMD) among migrant and non-migrant Africans is unknown. We aimed to examine differences in epigenetic age acceleration (EAA) as measured by four clocks (Horvath, Hannum, PhenoAge and GrimAge) and their associations with cardiometabolic factors among migrant Ghanaians in Europe and non-migrant Ghanaians.
Genome-wide DNA methylation (DNAm) data of 712 Ghanaians from cross-sectional RODAM study were used to quantify EAA. We assessed correlation of DNAmAge measures with chronological age, and then performed linear regressions to determine associations of body mass index (BMI), fasting blood glucose (FBG), blood pressure, alcohol consumption, smoking, physical activity, and one-carbon metabolism nutrients with EAA among migrant and non-migrants. We replicated our findings among 172 rural-urban sibling pairs from India migration study and among 120 native South Africans from PURE-SA-NW study.
We found that Ghanaian migrants have lower EAA than non-migrants. Within migrants, higher FBG was positively associated with EAA measures. Within non-migrants, higher BMI, and Vitamin B9 (folate) intake were negatively associated with EAA measures. Our findings on FBG, BMI and folate were replicated in the independent cohorts.
Our study shows that migration is negatively associated with EAA among Ghanaians. Moreover, cardiometabolic factors are differentially associated with EAA within migrant and non-migrant subgroups. Our results call for context-based interventions for CMD among transitioning populations that account for effects of biological aging.
European Commission.
非洲人口正经历着快速城市化和国际移民带来的健康转型。然而，在移民和非移民非洲人中，生物衰老在新兴的心血管代谢疾病（CMD）负担中的作用尚不清楚。我们旨在检查通过四个时钟（Horvath、Hannum、PhenoAge 和 GrimAge）测量的表观遗传年龄加速（EAA）在欧洲移民加纳人和非移民加纳人中的差异及其与心血管代谢因素的关系。
使用来自横向 RODAM 研究的 712 名加纳人的全基因组 DNA 甲基化（DNAm）数据来量化 EAA。我们评估了 DNAmAge 测量值与实际年龄的相关性，然后进行线性回归以确定体重指数（BMI）、空腹血糖（FBG）、血压、酒精摄入、吸烟、身体活动和一碳代谢营养素与移民和非移民 EAA 的关联。我们在来自印度移民研究的 172 对城乡兄弟姐妹和来自南非的 PURE-SA-NW 研究的 120 名本地南非人中复制了我们的发现。
我们发现加纳移民的 EAA 低于非移民。在移民中，较高的 FBG 与 EAA 测量值呈正相关。在非移民中，较高的 BMI 和维生素 B9（叶酸）摄入与 EAA 测量值呈负相关。我们在独立队列中复制了 FBG、BMI 和叶酸的发现。
我们的研究表明，移民与加纳人 EAA 呈负相关。此外，在移民和非移民亚组中，心血管代谢因素与 EAA 的相关性不同。我们的研究结果呼吁在转型人群中进行基于背景的干预措施，以考虑生物衰老的影响。
欧盟委员会。
