Department of Environmental Health Sciences, Mailman School of Public Health, New York (A.A.B.).
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, at Tufts University, Boston, MA (J.O.).
Circ Res. 2023 Jun 9;132(12):1648-1662. doi: 10.1161/CIRCRESAHA.123.322135. Epub 2023 Jun 8.
Epigenetics has transformed our understanding of the molecular basis of complex diseases, including cardiovascular and metabolic disorders. This review offers a comprehensive overview of the current state of knowledge on epigenetic processes implicated in cardiovascular and metabolic diseases, highlighting the potential of DNA methylation as a precision medicine biomarker and examining the impact of social determinants of health, gut bacterial epigenomics, noncoding RNA, and epitranscriptomics on disease development and progression. We discuss challenges and barriers to advancing cardiometabolic epigenetics research, along with the opportunities for novel preventive strategies, targeted therapies, and personalized medicine approaches that may arise from a better understanding of epigenetic processes. Emerging technologies, such as single-cell sequencing and epigenetic editing, hold the potential to further enhance our ability to dissect the complex interplay between genetic, environmental, and lifestyle factors. To translate research findings into clinical practice, interdisciplinary collaborations, technical and ethical considerations, and accessibility of resources and knowledge are crucial. Ultimately, the field of epigenetics has the potential to revolutionize the way we approach cardiovascular and metabolic diseases, paving the way for precision medicine and personalized health care, and improving the lives of millions of individuals worldwide affected by these conditions.
表观遗传学改变了我们对包括心血管和代谢紊乱在内的复杂疾病的分子基础的理解。这篇综述全面概述了与心血管和代谢疾病相关的表观遗传过程的最新知识，强调了 DNA 甲基化作为精准医学生物标志物的潜力，并探讨了健康的社会决定因素、肠道细菌表观基因组学、非编码 RNA 和表观转录组学对疾病发展和进展的影响。我们讨论了推进心脏代谢表观遗传学研究的挑战和障碍，以及从更好地理解表观遗传过程中可能出现的新型预防策略、靶向治疗和个性化医学方法的机会。新兴技术，如单细胞测序和表观遗传学编辑，有可能进一步增强我们剖析遗传、环境和生活方式因素之间复杂相互作用的能力。为了将研究成果转化为临床实践，跨学科合作、技术和伦理考虑以及资源和知识的可及性至关重要。最终，表观遗传学领域有可能彻底改变我们处理心血管和代谢疾病的方式，为精准医学和个性化医疗铺平道路，改善全球数以百万计受这些疾病影响的个体的生活。
