Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
BMJ Open. 2022 Dec 15;12(12):e067906. doi: 10.1136/bmjopen-2022-067906.
The Research on Obesity and Diabetes among African Migrants (RODAM) prospective (RODAM-Pros) cohort study was established to identify key changes in environmental exposures and epigenetic modifications driving the high burden of cardiovascular disease (CVD) risk among sub-Saharan African migrants.
All the participants in the RODAM cross-sectional study that completed the baseline assessment (n=5114) were eligible for the follow-up of which 2165 participants (n=638 from rural-Ghana, n=608 from urban-Ghana, and n=919 Ghanaian migrants in Amsterdam, the Netherlands) were included in the RODAM-Pros cohort study. Additionally, we included a subsample of European-Dutch (n=2098) to enable a comparison to be made between Ghanaian migrants living in the Netherlands and the European-Dutch host population.
Follow-up data have been collected on demographics, socioeconomic status, medical history, psychosocial environment, lifestyle factors, nutrition, anthropometrics, blood pressure, fasting blood, urine and stool samples. Biochemical analyses included glucose metabolism, lipid profile, electrolytes and renal function, liver metabolism and inflammation. In a subsample, we assessed DNA methylation patterns using Infinium 850K DNA Methylation BeadChip. Baseline results indicated that migrants have higher prevalence of CVD risk factors than non-migrants. Epigenome-wide association studies suggest important differences in DNA methylation between migrants and non-migrants. The follow-up study will shed further light on key-specific environmental exposures and epigenetic modifications contributing to the high burden of CVD risk among sub-Saharan African migrants.
Follow-up is planned at 5-year intervals, baseline completed in 2015 and first follow-up completed in 2021.
肥胖与糖尿病中的非裔移民研究（RODAM）前瞻性队列研究（RODAM-Pros）旨在确定环境暴露和表观遗传修饰的关键变化，这些变化驱动了撒哈拉以南非洲移民心血管疾病（CVD）风险的高负担。
所有完成基线评估的 RODAM 横断面研究的参与者（n=5114）都有资格进行随访，其中 2165 名参与者（n=638 名来自农村加纳，n=608 名来自城市加纳，以及 n=919 名加纳移民在荷兰阿姆斯特丹）被纳入 RODAM-Pros 队列研究。此外，我们还纳入了欧洲荷兰人（n=2098）的一个亚样本，以便能够对生活在荷兰的加纳移民与欧洲荷兰东道主人群进行比较。
已经收集了关于人口统计学、社会经济地位、病史、社会心理环境、生活方式因素、营养、人体测量学、血压、空腹血、尿液和粪便样本的随访数据。生化分析包括葡萄糖代谢、血脂谱、电解质和肾功能、肝脏代谢和炎症。在一个亚样本中，我们使用 Infinium 850K DNA 甲基化 BeadChip 评估了 DNA 甲基化模式。基线结果表明，移民的 CVD 危险因素患病率高于非移民。全基因组关联研究表明，移民和非移民之间的 DNA 甲基化存在重要差异。后续研究将进一步阐明导致撒哈拉以南非洲移民 CVD 风险负担高的特定环境暴露和表观遗传修饰。
随访计划每 5 年进行一次，基线于 2015 年完成，第一次随访于 2021 年完成。
