Liu He, Wu Taihong, Canales Xicotencatl Gracida, Wu Min, Choi Myung-Kyu, Duan Fengyun, Calarco John A, Zhang Yun
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Sci Adv. 2022 Feb 11;8(6):eabi9071. doi: 10.1126/sciadv.abi9071.
Forgetting is defined as a time-dependent decline of a memory. However, it is not clear whether forgetting reverses the learning process to return the brain to the naive state. Here, using the aversive olfactory learning of pathogenic bacteria in , we show that forgetting generates a novel state of the nervous system that is distinct from the naive state or the learned state. A transient exposure to the training condition or training odorants reactivates this novel state to elicit the previously learned behavior. An AMPA receptor and a type II serotonin receptor act in the central neuron of the learning circuit to decrease and increase the speed to reach this novel state, respectively. Together, our study systematically characterizes forgetting and uncovers conserved mechanisms underlying the rate of forgetting.
遗忘被定义为记忆随时间的衰退。然而，遗忘是否会逆转学习过程，使大脑恢复到未接触状态尚不清楚。在这里，我们利用对病原菌的厌恶嗅觉学习实验表明，遗忘会产生一种与未接触状态或学习状态不同的新型神经系统状态。短暂暴露于训练条件或训练气味剂会重新激活这种新型状态，从而引发先前学习到的行为。一种AMPA受体和一种II型血清素受体分别在学习回路的中枢神经元中发挥作用，降低和提高达到这种新型状态的速度。总之，我们的研究系统地表征了遗忘，并揭示了遗忘速率背后的保守机制。
