Medical Entomology, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Research & Development, Bayer AG Crop Science, Laboratory Vector Control, Field Testing, Monheim, Germany.
PLoS One. 2022 Feb 11;17(2):e0263840. doi: 10.1371/journal.pone.0263840. eCollection 2022.
Emergence and spread of malaria vectors resistant to the available insecticides required a new and efficacious insecticide. Residual efficacy of Fludora® Fusion was evaluated against insecticide susceptible Anopheles arabiensis in ten circular huts similar to the residential huts. Fludora® Fusion WP-SB 56.25, FICAM WP80 and Clothianidin WG70 were sprayed, by experienced technician, on interior wall surfaces: paint, dung, smooth mud, and rough mud. WHO cone bioassays were carried out a month after spraying and thereafter on monthly intervals for 12 months. Knockdown was recorded at 60 minutes and mortality at 24 hours, 48 hours and 72 hours holding time post-exposure. Fludora Fusion induced 100% An. arabiensis mortality during the first four months post-treated on all surface types at 24 hours holding time post-exposure. Its activity remained over 80% from the fifth to the twelfth month post-treated on the surfaces with the exception of two assessment points, at seventh month and eleventh month, on paint and smooth mud surfaces. FICAM induced 100% mortality rate during the first 4 months and 92% mortality during the fifth month post-treatment on painted surfaces. Its activity was over 96% mortality 1-month post-treatment on smooth mud and rough mud surfaces and 92% mortality 2-month post-treatment on dung surfaces. Clothianidin caused 89% and 86% mortality 1-month post-treatment on smooth mud and rough mud surfaces. Fludora Fusion can be used as alternative indoor residual insecticide spraying against An. arabiensis in Ethiopia.
疟原虫媒介对现有杀虫剂的抗药性的出现和传播需要一种新的、有效的杀虫剂。在十个类似于住宅的圆形小屋中，评估了 Fludora® Fusion 对敏感的按蚊的残留效果。由经验丰富的技术人员将 Fludora® Fusion WP-SB 56.25、FICAM WP80 和氯噻啉 WG70 喷洒到内墙表面：油漆、粪便、光滑的泥土和粗糙的泥土。在喷洒后一个月进行了 WHO 锥形生物测定，此后每月进行一次，共进行了 12 个月。在暴露后 60 分钟记录击倒率，24 小时、48 小时和 72 小时记录死亡率。在所有表面类型上，在暴露后 24 小时的持时，Fludora Fusion 在处理后的前四个月内诱导了 100%的按蚊死亡率。从第五个月到第十二个月，除了两个评估点，即第七个月和第十一个月，在油漆和光滑泥表面，其活性保持在 80%以上。在油漆表面，FICAM 在处理后的前四个月内诱导了 100%的死亡率，在处理后的第五个月内诱导了 92%的死亡率。在光滑的泥土和粗糙的泥土表面上，其活性在处理后 1 个月时超过 96%的死亡率，在粪便表面上，处理后 2 个月时超过 92%的死亡率。氯噻啉在光滑泥土和粗糙泥土表面上处理后 1 个月分别导致 89%和 86%的死亡率。Fludora Fusion 可以作为替代室内残留杀虫剂，用于在埃塞俄比亚对抗按蚊。
