Shanghai Pudong New Area Mental Health Centre, Shanghai, China.
Department of Psychiatric Rehabilitation, Shenzhen Kangning Hospital, Shenzhen, Guangdong, China.
BMC Pregnancy Childbirth. 2022 Feb 11;22(1):114. doi: 10.1186/s12884-022-04428-1.
Peripartum depression in and after pregnancy are common, reported by 11.9% of women worldwide, and the proportion was even higher during the outbreak of coronavirus disease 2019 (COVID-19). We aimed to investigate the prevalence and risk factors of peripartum depression under the influence of COVID-19 in China.
Using a cross-sectional design, 2026 pregnant and postpartum women residing in Beijing, Wuhan, and Lanzhou of China were recruited from February 28 to April 9, 2020. The Patient Health Questionnaire-9 was used to assess their depressive symptoms. The women were divided into four subgroups based on pregnancy stage, and a binary logistic regression analysis was conducted on each subgroup.
Under the influence of COVID-19, the prevalence rate of peripartum depression among Chinese women was 9.7%. It was 13.6, 10.8, 7.9 and 7.3% in the first, second, third trimester and puerperium, respectively. Regression analysis showed that the influence of current pregnancy status on movement (Mild vs. No, aORs were 3.89, P < 0.001, 2.92, P = 0.003, 1.58, P = 0.150 in the three trimesters, respectively; Severe vs. No, aORs were 13.00, 20.45, 5.38 in the three trimesters, respectively, all P < 0.05), and worries and fears about childbirth (aORs were 2.46, 2.96, 2.50 in the three trimesters, respectively, all P < 0.05) were associated with depression throughout pregnancy.
The prevalence rate of peripartum depression during the COVID-19 outbreak in China was not higher than usual. The influence of current pregnancy status on movement, as well as worries and fears about childbirth were independent risk factors for peripartum depression throughout pregnancy during COVID-19. The stage of pregnancy should be considered when implementing interventions.
围产期抑郁在妊娠期间和之后很常见，全球有 11.9%的女性报告了这种情况，而在 2019 年冠状病毒病（COVID-19）爆发期间，这一比例甚至更高。我们旨在研究在中国 COVID-19 影响下围产期抑郁的患病率和危险因素。
采用横断面设计，于 2020 年 2 月 28 日至 4 月 9 日招募了居住在北京、武汉和兰州的 2026 名孕妇和产后妇女。使用患者健康问卷-9 评估其抑郁症状。根据妊娠阶段将女性分为四组亚组，并对每组亚组进行二项逻辑回归分析。
在 COVID-19 的影响下，中国女性围产期抑郁的患病率为 9.7%。在第一、第二、第三孕期和产褥期分别为 13.6%、10.8%、7.9%和 7.3%。回归分析表明，当前妊娠状态对运动的影响（轻度与无，aOR 值分别为 3.89，P<0.001，2.92，P=0.003，1.58，P=0.150，分别在三个孕期；严重与无，aOR 值分别为 13.00，20.45，5.38，分别在三个孕期，均 P<0.05）以及对分娩的担忧和恐惧（aOR 值分别为 2.46，2.96，2.50，分别在三个孕期，均 P<0.05）与整个孕期的抑郁有关。
中国 COVID-19 爆发期间围产期抑郁的患病率并不高于平时。当前妊娠状态对运动的影响，以及对分娩的担忧和恐惧是 COVID-19 期间整个孕期围产期抑郁的独立危险因素。在实施干预措施时应考虑妊娠阶段。
