Unidad de Metodología. Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Bilbao, Spain.
Sección de Innovación y Organización, Servicio Navarro de Salud-Osasunbidea, Spain.
Transfus Apher Sci. 2022 Jun;61(3):103357. doi: 10.1016/j.transci.2022.103357. Epub 2022 Jan 17.
Since the beginning of the COVID-19 pandemic, the ABO blood group has been described as a possible biological marker of susceptibility for the disease. This study evaluates the role of ABO group on the risk of SARS-CoV-2 infection and related complications in a population-based cohort including 87,090 subjects from the Navarre population (Northern Spain) with no history of SARS-CoV-2 infection and with known ABO blood group, after one year of the pandemic (May 2020 - May 2021). The risk of infection, hospitalization, Intensive Care Unit (ICU) admission and death was analyzed using multivariate logistic regression, adjusting for possible confounding variables. A lower risk of infection was observed in group 0 vs non-0 groups [OR 0.94 (95 %CI 0.90-0.99)], a higher risk of infection in group A vs non-A groups [OR 1.09 (95 %CI 1.04-1.15)] and a higher risk of infection in group A vs group 0 [OR 1.08 (95CI 1.03-1.14)] (when the 4 groups are analyzed separately). No association was observed between blood groups and hospitalization, ICU admission, or death in SARS-CoV-2 infected subjects. Regarding the risk of SARS-CoV-2 infection, we observed a protective role of group O and a greater risk in the A group.
自 COVID-19 大流行开始以来，ABO 血型已被描述为疾病易感性的可能生物学标志物。本研究评估了 ABO 组在包括来自纳瓦拉人口（西班牙北部）的 87090 名无 SARS-CoV-2 感染史且已知 ABO 血型的人群中，在大流行一年后（2020 年 5 月至 2021 年 5 月）对 SARS-CoV-2 感染及相关并发症风险的作用。使用多变量逻辑回归分析感染、住院、重症监护病房（ICU）入院和死亡的风险，调整可能的混杂变量。与非 0 组相比，0 组的感染风险较低[OR 0.94（95 %CI 0.90-0.99)]，A 组的感染风险较高[OR 1.09（95 %CI 1.04-1.15)]，A 组的感染风险也高于 0 组[OR 1.08（95CI 1.03-1.14)]（当分别分析这 4 组时）。在 SARS-CoV-2 感染患者中，未观察到血型与住院、ICU 入院或死亡之间存在相关性。关于 SARS-CoV-2 感染的风险，我们观察到 O 组具有保护作用，而 A 组的风险更高。
