住院患者中 COVID-19 严重程度的 ABO 血型表型及临床相关性
ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients.
作者信息
Hermel David J, Spierling Bagsic Samantha R, Costantini Carrie L, Mason James R, Gahvari Zhubin J, Saven Alan
机构信息
Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
出版信息
Future Sci OA. 2021 Jun 12;7(8):FSO735. doi: 10.2144/fsoa-2021-0045. eCollection 2021 Sep.
AIM
This study investigates the association between ABO blood phenotype and COVID-19 severity, measured by intensive care unit admission, need for intubation, hospitalization length and death. It further explores clinical predictors of COVID-19 severity within a primarily Hispanic demographic in San Diego County.
MATERIALS & METHODS: We retrospectively reviewed 942 total patients, 473 with available blood type, hospitalized at five Scripps Health hospitals with COVID-19.
RESULTS
No significant association was found between ABO phenotype and COVID-19 severity on multivariate analysis, while a diagnosis of anemia and male sex was associated with all severity outcomes on exploratory analysis.
CONCLUSION
Our results provide relevant clinical correlates of COVID-19 severity and help better elucidate the association between ABO phenotype and COVID-19.
目的
本研究调查ABO血型表型与新型冠状病毒肺炎（COVID-19）严重程度之间的关联，以重症监护病房收治情况、插管需求、住院时长和死亡情况作为衡量指标。本研究还进一步探究了圣地亚哥县以西班牙裔为主的人群中COVID-19严重程度的临床预测因素。
材料与方法
我们回顾性分析了在斯克里普斯健康系统的五家医院住院治疗COVID-19的942例患者，其中473例患者有可用血型信息。
结果
多因素分析未发现ABO血型表型与COVID-19严重程度之间存在显著关联，而探索性分析发现贫血诊断和男性与所有严重程度结局相关。
结论
我们的研究结果提供了与COVID-19严重程度相关的临床关联因素，并有助于更好地阐明ABO血型表型与COVID-19之间的关联。
Zotero 插件