含蜂毒的局部纳米乳剂在大鼠中的抗风湿活性。
Anti-rheumatic activity of topical nanoemulsion containing bee venom in rats.
机构信息
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran; Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Eur J Pharm Biopharm. 2022 Mar;172:168-176. doi: 10.1016/j.ejpb.2022.02.005. Epub 2022 Feb 8.
PURPOSE
Bee Venom (BV) has been used to treat rheumatoid arthritis (RA) for many centuries. However, its clinical use is limited by pain and fear of bee stings/injection. Nanoemulsions (NEs) are nanocarriers that are able to help their content(s) penetrate through the skin. They also act as drug reservoirs on the skin to provide an efficient, sustained-release vehicle.
METHODS
In this paper, we present the development of a stable water-in-oil NE to help passing BV through the animal skin when used topically.
RESULTS
Particle size of NE was 12.7 to 29.8 nm for NEs containing 0 to 150 µg/ml BV. Also, its anti-inflammatory effects were evaluated in rat models of type II collagen-induced arthritis. Topical administration of NEs containing 18.75 or 9.37 μg/ml BV were able to significantly (p < 0.05) reduce inflammation in the rat paws compared to the blank and control groups.
CONCLUSION
Our findings demonstrated the efficacy of NEs containing BV to reduce inflammation caused by RA animal model.
目的
蜂毒（BV）已被用于治疗类风湿性关节炎（RA）数百年。然而，由于疼痛和对蜂蜇/注射的恐惧，其临床应用受到限制。纳米乳剂（NE）是纳米载体，能够帮助其内容物穿透皮肤。它们还可以作为皮肤上的药物储库，提供高效、持续释放的载体。
方法
本文介绍了一种稳定的油包水 NE 的开发，以帮助 BV 经皮给药时穿透动物皮肤。
结果
含 0 至 150μg/mlBV 的 NE 的粒径为 12.7 至 29.8nm。此外，还在 2 型胶原蛋白诱导的关节炎大鼠模型中评估了其抗炎作用。与空白组和对照组相比，含 18.75 或 9.37μg/mlBV 的 NE 经皮给药能够显著（p<0.05）减轻大鼠爪子的炎症。
结论
我们的研究结果表明，含 BV 的 NE 能够减轻 RA 动物模型引起的炎症。
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