Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, PR China.
University of Veterinary and Animal Sciences Lahore, 54000, Pakistan.
Virology. 2022 Mar;568:77-85. doi: 10.1016/j.virol.2022.02.001. Epub 2022 Feb 5.
Flaviviruses are a group of enveloped viruses that enter the host cells through receptor-mediated endocytosis. The entry of flaviviruses into the cells is a multi-step process which involves several host factors that trigger the uptake of the virus. The initial step in the virus life cycle is the interactions between viral envelope proteins and the specific receptors on the surface of host cell. To date, several receptors have been identified such as glycosaminoglycans, tight junction proteins, laminin receptor and phosphatidylserine receptors. Moreover, the viruses may utilize integrins and C-type lectin receptors on the surface of host cells as the initial attachment factors. This mini-review will focus on recent progresses in the understanding of virus attachment, internalization, and membrane fusion with specific emphasis on the cellular receptors.
黄病毒是一类包膜病毒，通过受体介导的内吞作用进入宿主细胞。黄病毒进入细胞是一个多步骤的过程，涉及到几个宿主因子，这些因子触发病毒的摄取。病毒生命周期的初始步骤是病毒包膜蛋白与宿主细胞膜表面的特定受体之间的相互作用。迄今为止，已经鉴定出几种受体，如糖胺聚糖、紧密连接蛋白、层粘连蛋白受体和磷脂酰丝氨酸受体。此外，病毒可能利用宿主细胞表面的整合素和 C 型凝集素受体作为初始附着因子。本综述将重点介绍病毒附着、内化和膜融合的最新进展，特别强调细胞受体。
