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在阿姆斯特丹的性健康诊所就诊的有症状和无症状的男男性行为者中很常见。

is common in symptomatic and asymptomatic men who have sex with men visiting a sexual health clinic in Amsterdam.

机构信息

Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands

Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.

出版信息

Sex Transm Infect. 2022 Dec;98(8):564-569. doi: 10.1136/sextrans-2021-055274. Epub 2022 Feb 11.

DOI:10.1136/sextrans-2021-055274
PMID:35149579
Abstract

INTRODUCTION

Shigellosis is a reportable infectious disease. It can present as a severe bloody diarrhoea but is often asymptomatic. can be sexually transmissible. We performed a study among symptomatic and asymptomatic men who have sex with men (MSM) to assess the prevalence of and .

METHODS

From March to June 2020, MSM attending the Amsterdam centre for sexual health were consecutively included. Predefined minimal numbers of inclusion of 150, 100 and 50 were determined, respectively, for MSM who reported no diarrhoea, diarrhoea during last month or diarrhoea on the day of visit to clinic. Anal samples were tested for the presence of , and . During the same period, the frequency of these bacteria was assessed in routinely tested samples requested by general physicians or nursing home physicians. Characteristics of included MSM were compared between the men with different diarrhoea anamnesis, and the prevalence of shigellosis was estimated in each group.

RESULTS

We included 212 MSM without diarrhoea, 109 MSM who recently had diarrhoea and 68 MSM who reported diarrhoea on the day of clinic visit. Thirteen (3.3%, 95% CI 1.7% to 5.6%) MSM were infected with , none with and 7 (1.8%, 95% CI 0.7% to 3.7%) with prevalence was 2.8% (95% CI 1.0% to 6.1%) in asymptomatic men, 3.7% (95% CI 1.0% to 9.1%) in men who recently had diarrhoea and 4.4% (95% CI 0.9% to 12.4%) in men with current diarrhoea (p=0.799). was more frequently found in MSM who had used pre-exposure prophylaxis (PrEP) in the preceding 3 months (10/151), compared with those not having used PrEP (2/146) or being HIV positive (1/75) (p=0.038). was significantly more often detected among MSM compared with routinely obtained faecal samples being 11/770 (1.4%) (p=0.031).

CONCLUSION

infections are relatively common in both symptomatic and asymptomatic MSM. Future studies should focus on the risk of onward transmission via asymptomatic persons. Shigellose is een meldingsplichtige infectieziekte. Het kan zich presenteren als een ernstige bloederige diarree, maar is vaak asymptomatisch. kan seksueel overdraagbaar zijn. We hebben een onderzoek uitgevoerd onder symptomatische en asymptomatische mannen die seks hebben met mannen (MSM) om de prevalentie van en te bepalen. Van maart tot juni 2020 werden achtereenvolgens MSM van het Amsterdamse centrum voor seksuele gezondheid opgenomen. Vooraf gedefinieerde minimale aantallen van inclusie van respectievelijk 150, 100 en 50 waren bepaald voor MSM die geen diarree, diarree in de afgelopen maand of diarree op de dag van bezoek aan de kliniek meldden. Anale monsters werden getest op de aanwezigheid van en . In dezelfde periode werd de frequentie van deze bacteriën bepaald in routinematig geteste monsters aangevraagd door huisartsen of verpleeghuisartsen. Kenmerken van geïncludeerde MSM werden vergeleken tussen mannen met verschillende diarree anamnese, en de prevalentie van shigellose werd in elke groep geschat. We includeerden 212 MSM zonder diarree, 109 MSM die onlangs diarree hadden en 68 MSM die diarree meldden op de dag van het bezoek aan de kliniek. Dertien (3,3%, 95% CI 1,7-5,6%) MSM waren geïnfecteerd met , geen enkele met , en 7 (1,8%, 95% CI 0,7-3,7%) met . De prevalentie van was 2,8% (95%CI 1,0-6,1%) bij asymptomatische mannen, 3,7% (95%CI 1,0-9,1%) bij mannen die recent diarree hadden en 4,4% (95%CI 0,9-12,4%) bij mannen met huidige diarree (P=0,799). werd vaker gevonden bij MSM die in de voorgaande drie maanden (10/151) PrEP hadden gebruikt dan bij mensen die geen PrEP hadden gebruikt (2/146) of hiv-positief waren (1/75) (p=0,038). werd significant vaker gedetecteerd bij MSM in vergelijking met routinematig verkregen fecale monsters, namelijk 11/770 (1,4%) (p=0,031). infecties komen relatief vaak voor bij zowel symptomatische als asymptomatische MSM. Toekomstige studies moeten zich richten op het risico van verdere overdracht via asymptomatische personen.

摘要

简介

志贺菌病是一种应报告的传染病。它可以表现为严重的血性腹泻,但通常无症状。可通过性传播。我们对有症状和无症状的男男性行为者(MSM)进行了一项研究,以评估 和 的流行率。

方法

2020 年 3 月至 6 月,连续纳入阿姆斯特丹性健康中心就诊的 MSM。分别确定了报告无腹泻、上月腹泻或就诊当天腹泻的 MSM 的最小纳入人数为 150、100 和 50。分析了 、 、 存在于肛门样本中的情况。在同一时期,评估了常规要求的由全科医生或养老院医生送检的样本中这些细菌的频率。对不同腹泻病史的 MSM 进行了比较,估计了每组的志贺菌病流行率。

结果

我们纳入了 212 名无腹泻的 MSM、109 名近期腹泻的 MSM 和 68 名就诊当天腹泻的 MSM。13 名(3.3%,95%CI 1.7%至 5.6%)MSM 感染了 ,无感染 ,7 名(1.8%,95%CI 0.7%至 3.7%)感染了 。无症状男性中 的患病率为 2.8%(95%CI 1.0%至 6.1%),近期腹泻的男性中为 3.7%(95%CI 1.0%至 9.1%),当前腹泻的男性中为 4.4%(95%CI 0.9%至 12.4%)(p=0.799)。在过去 3 个月内使用过暴露前预防(PrEP)的 MSM 中, 检出率较高(10/151),与未使用 PrEP 或 HIV 阳性的 MSM 相比(2/146,1/75)(p=0.038)。 与常规获得的粪便样本相比,在 MSM 中更为常见,阳性率为 11/770(1.4%)(p=0.031)。

结论

感染 在有症状和无症状的 MSM 中都很常见。未来的研究应关注无症状感染者的传播风险。

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