Zekeridou Anastasia, Yang Binxia, Lennon Vanda A, Guo Yong, Wu Liang, Lucchinetti Claudia F, McKeon Andrew, Pittock Sean J, Flanagan Eoin P
Department of Neurology, Mayo Clinic, Rochester, MN.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Ann Neurol. 2022 May;91(5):670-675. doi: 10.1002/ana.26320. Epub 2022 Mar 3.
The antigen specificity of Anti-Neuronal Nuclear Antibody-type 3 (ANNA3)-IgG is unknown. We identified Dachshund-homolog 1 (DACH1) as the ANNA3 autoantigen and confirmed it by antigen-specific assays, immunohistochemical colocalization and immune absorption experiments. Patients' median age was 63.5 years (range, 49-88); 67% were female. Neurological manifestations (information available for 30 patients) included one or more of neuropathy, 12; cognitive difficulties, 11; ataxia, 8; dysautonomia, 7. Evidence of a neoplasm was present in 27 of 30 (90%), most of neuroendocrine lineage. DACH1-IgG is rare and represents a novel proposed biomarker of neurological autoimmunity and cancer. ANN NEUROL 2022;91:670-675.
抗神经元核抗体3型（ANNA3）-IgG的抗原特异性尚不清楚。我们将果蝇同源蛋白1（DACH1）鉴定为ANNA3自身抗原，并通过抗原特异性检测、免疫组化共定位和免疫吸收实验进行了证实。患者的中位年龄为63.5岁（范围49 - 88岁）；67%为女性。神经学表现（30例患者的可用信息）包括一种或多种神经病变（12例）、认知困难（11例）、共济失调（8例）、自主神经功能障碍（7例）。30例中有27例（90%）存在肿瘤证据，大多数为神经内分泌谱系。DACH1-IgG很罕见，是一种新提出的神经自身免疫和癌症生物标志物。《神经病学纪事》2022年；91:670 - 675。
