应用 OCT 血管造影评估甲状腺相关眼病（TAO）患者的视盘周围血管血流。
Evaluation of peripapillary vascular flow in patients with Thyroid-Associated Ophthalmopathy (TAO) by OCT Angiography.
机构信息
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University Eye Clinic of Genoa, IRCCS Ospedale Policlinico S. Martino, Genova, Italy.
Ophthalmology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna and S.Orsola-Malpighi Teaching Hospital, Bologna, Italy.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2022 Aug;260(8):2711-2716. doi: 10.1007/s00417-022-05551-7. Epub 2022 Feb 12.
PURPOSE
To evaluate changes in peripapillary vascular blood flow indices (PVBFI) in patients with thyroid-associated ophthalmopathy (TAO) using OCT angiography (OCTA) technology.
METHODS
Patients with TAO and control subjects matched for age and sex were included in the study. Eye examination, Clinical Activity Score (CAS) evaluation and OCTA scan analysis (Topcon ImageNet 6; DRI OCT Triton, Topcon Corporation) were performed. In particular, PVBFI of the superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina (OR) and choriocapillaris (CC) layers were obtained by OCTA and extracted from 8-bit greyscale OCT images using the ImageJ software package.
RESULTS
Twenty-six patients with TAO (19 females, mean age 54.7 ± 5.2 and 7 males, mean age 51.4 ± 16.3) were compared with 26 healthy subjects (15 females, mean age 48.2 ± 14.1 and 11 males, mean age 53.1 ± 15.2). Both DCP-PVBF and CC-PVBFI were significantly reduced in TAO patients compared to control eyes (28.6 ± 2.1 vs. 29.7 ± 0.93, p = 0.002; 46.5 ± 1.72 vs. 47.2 ± 1.2, p = 0.019 respectively); on the other hand, no statistically significant differences were found in SCP-PVBFI and OR-PVBFI in TAO patients compared to healthy subjects (p > 0.05). Also, CC-PVBFI was associated with elevated values of CAS (p = 0.018) and ROC curve showed that patients with elevated CC-PVBFI were correlated with active TAO (CAS > 3) (p = 0.012).
CONCLUSIONS
TAO disease may be associated with changes in DCP-PVBFI and CC-PVBFI; also, CC-PVBFI seems to correlate with disease activity.
目的
利用 OCT 血管造影术（OCTA）评估甲状腺相关眼病（TAO）患者的视盘周围血管血流指数（PVBFI）的变化。
方法
本研究纳入了 TAO 患者和年龄、性别相匹配的对照组。进行眼部检查、临床活动评分（CAS）评估和 OCTA 扫描分析（Topcon ImageNet 6；DRI OCT Triton，Topcon 公司）。特别地，使用 OCTA 从 8 位灰度 OCT 图像中提取并获得浅层毛细血管丛（SCP）、深层毛细血管丛（DCP）、外视网膜（OR）和脉络膜毛细血管（CC）层的 PVBFI。
结果
将 26 例 TAO 患者（19 名女性，平均年龄 54.7±5.2 岁，7 名男性，平均年龄 51.4±16.3 岁）与 26 名健康对照者（15 名女性，平均年龄 48.2±14.1 岁，11 名男性，平均年龄 53.1±15.2 岁）进行比较。与对照组相比，TAO 患者的 DCP-PVBF 和 CC-PVBFI 均显著降低（28.6±2.1 对 29.7±0.93，p=0.002；46.5±1.72 对 47.2±1.2，p=0.019）；另一方面，在 TAO 患者与健康对照者之间，SCP-PVBFI 和 OR-PVBFI 没有统计学上的显著差异（p>0.05）。此外，CC-PVBFI 与 CAS 升高值相关（p=0.018），ROC 曲线表明，CC-PVBFI 升高的患者与活动性 TAO（CAS>3）相关（p=0.012）。
结论
TAO 疾病可能与 DCP-PVBFI 和 CC-PVBFI 的变化有关；此外，CC-PVBFI 似乎与疾病的活动度相关。
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