Gumina S, Villani C, Carbone S, Venditto T, Candela V
Department of Anatomy, Histology, Legal Medicine and Orthopaedics, Sapienza University of Rome, Italy.
ICOT, Latina, Italy.
Shoulder Elbow. 2022 Feb;14(1):55-59. doi: 10.1177/1758573220947027. Epub 2020 Aug 10.
Glenoid version is the most variable parameter of the shoulder joint. No authors investigated if intrinsic genetic factors or influences from extrinsic sources are responsible for its variability.
We compared glenoid version between elderly monozygotic and dizygotic twins intending to separate the contributions of genetics from shared and unique environments.
Glenoid version of the dominant shoulder was assessed by MRI using Friedman's method in 30 pairs of elderly twins (16 monozygotic-14 dizygotic; mean age ± SD: 63.72 ± 3.37, 53-72). Heritability was estimated as twice the difference between the intraclass correlation coefficients for monozygotic and dizygotic pairs. The influence of shared environment was calculated as the difference between monozygotic correlation coefficient and the heritability index. According to job category, one way analysis of variance was used to estimate the differences between groups in the total sample and within zygosity groups.
Glenoid version angle in monozygotic and dizygotic twins was -2° (SD: 2°) and -3° (SD: 3°), respectively (p = 0.334). Heritability index was 0.98, while the contributions of shared and unique environment were 0 and 0.02, respectively. According to working classes, no significant differences were found between the groups (p = 0.732, F = 0.31).
Glenoid version is mainly genetically determined and only marginally influenced by environments. III.
肩胛盂方向是肩关节最具变异性的参数。尚无作者研究其变异性是由内在遗传因素还是外在因素影响所致。
我们比较了老年同卵双胞胎和异卵双胞胎之间的肩胛盂方向，旨在区分遗传因素与共同环境和独特环境的影响。
采用弗里德曼方法，通过MRI对30对老年双胞胎（16对同卵双胞胎 - 14对异卵双胞胎；平均年龄±标准差：63.72±3.37，53 - 72岁）优势侧肩关节的肩胛盂方向进行评估。遗传度估计为同卵双胞胎和异卵双胞胎组内相关系数差值的两倍。共同环境的影响计算为同卵双胞胎相关系数与遗传度指数的差值。根据工作类别，采用单因素方差分析估计总样本组间以及同卵双生子组内的差异。
同卵双胞胎和异卵双胞胎的肩胛盂方向角分别为-2°（标准差：2°）和-3°（标准差：3°）（p = 0.334）。遗传度指数为0.98，而共同环境和独特环境的影响分别为0和0.02。根据工作类别，各组之间未发现显著差异（p = 0.732，F = 0.31）。
肩胛盂方向主要由遗传决定，仅受环境的轻微影响。III.
