Beyaz Metin O, Bozkurt Emre, Onalan Mehmet A, Oztas Didem M, Meric Mert, Ulukan Mustafa Ozer, Coskun Ugur, Ugurlucan Murat
Cardiovascular Surgery Clinic, Umraniye Education and Research Hospital, Istanbul, Turkey.
General Surgery Clinic, Gumushane Kelkit Hospital, Gumushane, Turkey.
Arch Med Sci. 2019 May 17;18(1):129-132. doi: 10.5114/aoms.2019.85232. eCollection 2022.
Lower extremity venous insufficiency is a significant health problem with economic and sociological consequences, lowering the quality of life, and sometimes leading to serious complications. The aim of this study is to evaluate the cytomegalovirus (CMV) effect on chronic inflammation in the aetiology of chronic venous insufficiency.
Between November 2017 and August 2018, 468 patients who underwent radio-frequency ablation therapy and phlebectomy were included in the study. PCR analyses for CMV DNA were performed on the venous tissue samples. Patients with post-thrombotic syndrome were excluded from the study. After ethical approval, the relationship between the presence of CMV DNA, gender, body mass index, and bilaterality of chronic venous insufficiency were investigated.
When the relationship between CMV DNA and gender or body mass index was examined, a significant relationship was not detected. But when the patients with bilateral chronic venous insufficiency and patients with unilateral chronic venous insufficiency were compared regarding CMV DNA positivity, the patients with bilateral chronic venous insufficiency had significantly higher CMV DNA positivity ( = 0.002). Also, the incidence of venous ulcers in the CMV DNA exposed group was significantly higher.
In the literature there are many studies showing that CMV triggers atherosclerosis, but there is no study in which CMV directly produces chronic venous insufficiency. The high rates of positivity suggest that CMV, which is the basis of chronic inflammation, may be a significant factor in the aetiology of chronic venous insufficiency.
下肢静脉功能不全是一个严重的健康问题，会产生经济和社会学后果，降低生活质量，有时还会导致严重并发症。本研究的目的是评估巨细胞病毒（CMV）在慢性静脉功能不全病因中对慢性炎症的影响。
2017年11月至2018年8月期间，468例行射频消融治疗和静脉切除术的患者纳入本研究。对静脉组织样本进行CMV DNA的PCR分析。血栓形成后综合征患者被排除在研究之外。经伦理批准后，研究CMV DNA的存在与慢性静脉功能不全的性别、体重指数和双侧性之间的关系。
检查CMV DNA与性别或体重指数之间的关系时，未发现显著关系。但比较双侧慢性静脉功能不全患者和单侧慢性静脉功能不全患者的CMV DNA阳性情况时，双侧慢性静脉功能不全患者的CMV DNA阳性率显著更高（P = 0.002）。此外，CMV DNA暴露组的静脉溃疡发生率显著更高。
文献中有许多研究表明CMV引发动脉粥样硬化，但尚无CMV直接导致慢性静脉功能不全的研究。高阳性率表明，作为慢性炎症基础的CMV可能是慢性静脉功能不全病因中的一个重要因素。
