Taheri Ehsaneh, Moslem Alireza, Mousavi-Jarrahi Alireza, Hatami Behzad, Pourhoseingholi Mohammad Amin, Asadzadeh Aghdaei Hamid, Zali Mohammad Reza
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Science, Tehran, Iran.
Cellular and Molecular Research Center, Sabzevar University of Medical Science, Sabzevar, Iran.
Gastroenterol Hepatol Bed Bench. 2021 Fall;14(Suppl1):S102-S111.
This study aimed to identify the risk factors of metabolic (dysfunction)-associated fatty liver disease (MAFLD) among adults in northeastern Iran.
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and hepatic manifestation of metabolic syndrome that threatens global public health. Recently, MAFLD has been proposed as a new terminology updated from NAFLD and diagnosed based on modified criteria.
A nested case-control study was performed on the participants of the first phase of the Persian Sabzevar Cohort Study (PSCS), a survey that was conducted in northeastern Iran and enrolled 4,242 participants aged 35-70 years. In total, 968 MAFLD cases and 964 controls adjusted for age and sex were recruited. Data including demographic, lifestyle, anthropometric, biochemical, sleep pattern, and dietary intake information was collected.
The mean (SD [standard deviation]) age of participants was 49.2 (8.8) years, and 39.9% of the participants were males. The prevalence of MAFLD was 22.8% (95% CI [confidence interval] 19.2 - 26.3%). Increased body mass index (BMI) (OR [odds ratios] 5.51, 95% CI 2.73 - 11.10), waist circumference (WC) (OR 1.85, 95% CI 1.44 - 2.38), blood concentrations of triglycerides (TG) (OR 1.10, 95% CI 1.06 - 1.15), total cholesterol (TC) (OR 1.02, 95% CI 1.003 - 1.04), and alanine aminotransferase (AST) (OR 1.10, 95% CI 1.05 - 1.16) were significantly associated with an increased risk of the MAFLD (value <0.05). Furthermore, the odds of MAFLD risk was 43% higher in subjects who slept ≤ 5 hrs/day than those with ≥ 7 hrs per day of sleep (OR 1.43; 95% CI 1.07 - 1.92, value = 0.01).
In this study, it was found that MAFLD was best predicted by BMI, WC, and serum levels of TG, total cholesterol, and AST. Sleeping ≤ 5hrs/day compared to ≥ 7hrs/day was associated with an increased risk of MAFLD.
本研究旨在确定伊朗东北部成年人中代谢（功能障碍）相关脂肪性肝病（MAFLD）的危险因素。
非酒精性脂肪性肝病（NAFLD）是慢性肝病最常见的病因，也是代谢综合征的肝脏表现，威胁着全球公共卫生。最近，MAFLD被提议作为从NAFLD更新而来的新术语，并根据修改后的标准进行诊断。
对波斯萨卜泽瓦尔队列研究（PSCS）第一阶段的参与者进行了一项巢式病例对照研究，该研究在伊朗东北部进行，纳入了4242名年龄在35至70岁之间的参与者。总共招募了968例MAFLD病例和964例按年龄和性别调整后的对照。收集了包括人口统计学、生活方式、人体测量学、生化、睡眠模式和饮食摄入信息在内的数据。
参与者的平均（标准差[SD]）年龄为49.2（8.8）岁，39.9%的参与者为男性。MAFLD的患病率为22.8%（95%置信区间[CI]19.2 - 26.3%）。体重指数（BMI）升高（比值比[OR]5.51，95%CI 2.73 - 11.10）、腰围（WC）（OR 1.85，95%CI 1.44 - 2.38）、甘油三酯（TG）血浓度（OR 1.10，95%CI 1.06 - 1.15）、总胆固醇（TC）（OR 1.02，95%CI 1.003 - 1.04）和丙氨酸氨基转移酶（AST）（OR 1.10，95%CI 1.05 - 1.16）与MAFLD风险增加显著相关（P值<0.05）。此外，每天睡眠≤5小时的受试者患MAFLD风险的几率比每天睡眠≥7小时的受试者高43%（OR 1.43；95%CI 1.07 - 1.92，P值 = 0.01）。
在本研究中，发现BMI、WC以及TG、总胆固醇和AST的血清水平对MAFLD的预测效果最佳。与每天睡眠≥7小时相比，每天睡眠≤5小时与MAFLD风险增加相关。
