Taheri Ehsaneh, Pourhoseingholi Mohammad Amin, Moslem Alireza, Hassani Amir Hossein, Mousavi Jarrahi Alireza, Asadzadeh Aghdaei Hamid, Zali Mohammad Reza, Hatami Behzad
Student Research Committee, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gasteroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Diabetes Metab Disord. 2022 Jan 11;21(1):97-107. doi: 10.1007/s40200-021-00941-w. eCollection 2022 Jun.
There is a bi-directional association between non-alcoholic fatty liver disease (NAFLD) and insulin resistance in type 2 diabetes mellitus (T2DM) and metabolic syndrome. The triglyceride-glucose (TyG) index is a novel surrogate marker of insulin resistance. In this population-based study, we aimed firstly to investigate the association of the TyG-index with metabolic-associated fatty liver disease (MAFLD) risk.
This case-control study used the data from the first phase of the Persian Cohort Study in Sabzevar. Of 4,241 participants aged 35 to 70 years, we identified and recruited 968 MAFLD cases and 964 age- and sex-adjusted controls. Demographic, lifestyle, anthropometric, and biochemical information were collected. We calculated TyG and a new index combined of TyG and alanine aminotransferase (TyG-ALT). We used the multivariable unconditional logistic regression model to calculate the odds ratios (ORs) of the TyG and TyG-ALT for having MAFLD.
Among those in the highest relative to the lowest TyG and TyG-ALT tertiles, the multivariable-adjusted ORs were 12.01 (95% CI [confidence interval] 9.03 - 15.98; < 0.001) and 10.89 (95% CI 7.66 - 15.48; = 0.001), respectively. The area under the curves (AUC) for the TyG-index to predict MAFLD was 8.62, resulting in a cut-off value of 8.62 with a sensitivity of 81.66% and specificity of 75.36%.
The higher TyG and TyG-ALT scores were significantly positively associated with higher MAFLD risk in the Iranian population.
非酒精性脂肪性肝病（NAFLD）与2型糖尿病（T2DM）及代谢综合征中的胰岛素抵抗之间存在双向关联。甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗的一种新型替代标志物。在这项基于人群的研究中，我们首先旨在探究TyG指数与代谢相关脂肪性肝病（MAFLD）风险之间的关联。
这项病例对照研究使用了来自萨卜泽瓦尔波斯队列研究第一阶段的数据。在4241名年龄在35至70岁的参与者中，我们确定并招募了968例MAFLD病例和964名年龄及性别匹配的对照。收集了人口统计学、生活方式、人体测量学和生化信息。我们计算了TyG以及TyG与丙氨酸氨基转移酶的新组合指数（TyG-ALT）。我们使用多变量无条件逻辑回归模型来计算TyG和TyG-ALT患MAFLD的比值比（OR）。
在TyG和TyG-ALT三分位数最高组相对于最低组中，多变量调整后的OR分别为12.01（95%置信区间[CI] 9.03 - 15.98；P < 0.001）和10.89（95% CI 7.66 - 15.48；P = 0.001）。TyG指数预测MAFLD的曲线下面积（AUC）为8.62，截断值为8.62，敏感性为81.66%，特异性为75.36%。
在伊朗人群中，较高的TyG和TyG-ALT得分与较高的MAFLD风险显著正相关。
