Isidoro Ciro, Chiung-Fang Chang Ashley, Sheen Lee-Yan
Università del Piemonte Orientale, Department of Health Sciences, Novara, Italy.
National Taiwan University, Institute of Food Science and Technology, Taipei, Taiwan.
J Tradit Complement Med. 2022 Jan;12(1):1-5. doi: 10.1016/j.jtcme.2022.02.001. Epub 2022 Feb 8.
COVID-19, the infectious disease caused by the beta-corona virus SARS-CoV2, has posed a global health threat causing more than five million of deaths in the last two years in the world. Although the disease often presents with mild cold-like symptoms, it may have lethal consequences following thromboembolisms, hyperinflammation and cytokine storm eventually leading to pulmonary fibrosis and multiple organ failure. Despite the progress made in the understanding of the SARS-CoV2 pathology and the clinical management of COVID-19, the viral illness is still a health concern since outbreaks continue to resurge due to the emergence of mutant variants of the virus that resist the vaccines. Therefore, there is an urgent need for therapeutics that can block SARS-CoV2 viral transmission and the progression from infection to severe symptomatic illness. Natural products could be a valuable source of drugs for the management of COVID-19 disease, particularly because they can act on multitargets and through different mechanisms including inhibition of biochemical pathways, epigenetic regulation of gene expression, modulation of immune response, regulation of pathophysiological stress response. Here we present an overview of the natural products that possess SARS-CoV2 antiviral activity and the potential to benefit the management of COVID-19.
新冠病毒病（COVID-19）是由β冠状病毒严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的传染病，在过去两年里对全球健康构成了威胁，已导致全球超过500万人死亡。尽管该病通常表现为类似感冒的轻微症状，但在发生血栓栓塞、过度炎症反应和细胞因子风暴后可能产生致命后果，最终导致肺纤维化和多器官衰竭。尽管在了解SARS-CoV-2病理和COVID-19临床管理方面取得了进展，但由于抵抗疫苗的病毒突变变种的出现，疫情仍不断复发，这种病毒性疾病仍是一个健康问题。因此，迫切需要能够阻断SARS-CoV-2病毒传播以及从感染发展到严重症状性疾病进程的治疗方法。天然产物可能是治疗COVID-19疾病的宝贵药物来源，特别是因为它们可以作用于多个靶点，并通过不同机制发挥作用，包括抑制生化途径、基因表达的表观遗传调控、免疫反应的调节、病理生理应激反应的调节。在此，我们概述了具有抗SARS-CoV-2病毒活性且有可能有助于COVID-19治疗的天然产物。
