剪切波弹性成像用于评估乳腺癌生物学行为的可行性
Feasibility of Shear Wave Elastography Imaging for Evaluating the Biological Behavior of Breast Cancer.
作者信息
Liu Chaoxu, Zhou Jin, Chang Cai, Zhi Wenxiang
机构信息
Department of Ultrasonography, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China.
出版信息
Front Oncol. 2022 Jan 27;11:820102. doi: 10.3389/fonc.2021.820102. eCollection 2021.
OBJECTIVE
To explore the feasibility of shear wave elastography (SWE) parameters for assessing the biological behavior of breast cancer.
MATERIALS AND METHODS
In this prospective study, 224 breast cancer lesions in 216 female patients were examined by B-mode ultrasound and shear wave elastography in sequence. The maximum size (S) of the lesion was measured by B-mode ultrasound, and then shear wave elastography was performed on this section to obtain relevant parameters, including maximum elasticity (E), mean elasticity (E), standard deviation of elasticity (SD), and the area ratio of shear wave elastography to B-mode ultrasound (AR). The relationship between SWE parameters and pathological type, histopathological classification, histological grade, lymphovascular invasion status (LVI), axillary lymph node status (ALN), and immunohistochemistry of breast cancer lesions was performed according to postoperative pathology.
RESULTS
In the univariate analysis, the pathological type and histopathological classification of breast cancer were not significantly associated with SWE parameters; with an increase in the histological grade of invasive ductal carcinoma (IDC), SD ( = 0.016) and S ( = 0.000) values increased. In the ALN-positive group, S ( = 0.004) was significantly greater than in the ALN-negative group; S ( = 0.003), E ( = 0.034), and SD ( = 0.045) were significantly higher in the LVI-positive group than in the LVI-negative group; SD ( = 0.043, = 0.047) and S ( = 0.000, = 0.000) were significantly lower in the ER and PR groups than in the ER and PR groups, respectively; AR ( = 0.032) was significantly higher in the ER groups than in the ER groups, and S ( = 0.002) of the HER2 group showed higher values than that of the HER2 group; S ( = 0.000), SD ( = 0.006), and E ( = 0.004) of the Ki-67 high-expression group showed significantly higher values than those of the Ki-67 low-expression group. In the multivariate analysis, Ki-67 was an independent factor of S ( = 0.005), E ( = 0.004), and SD ( = 0.006); ER was an independent influencing factor of S ( = 0.000) and AR ( = 0.032). LVI independently influences S ( = 0.006).
CONCLUSIONS
The SWE parameters E, SD, and AR can be used to evaluate the biological behavior of breast cancer.
目的
探讨剪切波弹性成像（SWE）参数评估乳腺癌生物学行为的可行性。
材料与方法
本前瞻性研究中，对216例女性患者的224个乳腺癌病灶依次进行B超和剪切波弹性成像检查。用B超测量病灶最大径（S），然后在该层面行剪切波弹性成像以获取相关参数，包括最大弹性值（E）、平均弹性值（E）、弹性值标准差（SD）以及剪切波弹性成像与B超面积比（AR）。根据术后病理分析SWE参数与乳腺癌病灶病理类型、组织病理学分类、组织学分级、脉管浸润情况（LVI）、腋窝淋巴结状态（ALN）及免疫组化的关系。
结果
单因素分析中，乳腺癌的病理类型和组织病理学分类与SWE参数无显著相关性；浸润性导管癌（IDC）组织学分级升高，SD值（ = 0.016）和S值（ = 0.000）升高。ALN阳性组S值（ = 0.004）显著大于ALN阴性组；LVI阳性组S值（ = 0.003）、E值（ = 0.034）和SD值（ = 0.045）显著高于LVI阴性组；ER和PR阳性组SD值（分别为 = 0.043、 = 0.047）和S值（分别为 = 0.000、 = 0.000）显著低于ER和PR阴性组；ER阳性组AR值（ = 0.032）显著高于ER阴性组，HER2阳性组S值（ = 0.002）高于HER2阴性组；Ki-67高表达组S值（ = 0.000）、SD值（ = 0.006）和E值（ = 0.004）显著高于Ki-67低表达组。多因素分析中，Ki-67是S值（ = 0.005）、E值（ = 0.004）和SD值（ = 0.006）的独立影响因素；ER是S值（ = 0.000）和AR值（ = 0.032）的独立影响因素。LVI独立影响S值（ = 0.006）。
结论
SWE参数E、SD和AR可用于评估乳腺癌的生物学行为。
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