Department of Ultrasonography, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, No 270, Dong'an Road, Xuhui District, Shanghai 200032, China.
Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Acad Radiol. 2024 Sep;31(9):3489-3498. doi: 10.1016/j.acra.2024.03.006. Epub 2024 Mar 27.
Shear Wave Elastography (SWE) and Ultrasound-guided Diffuse Optical Tomography (US-guided DOT) demonstrate promise in distinguishing between benign and malignant breast lesions. This study aims to assess the feasibility and correlation of SWE and US-guided DOT in evaluating the biological characteristics of breast cancer.
A cohort of 235 breast cancer patients with 238 lesions, scheduled for surgery within one to three days, underwent B-mode ultrasound (US), US-guided DOT, and SWE. Parameters such as Total Hemoglobin Concentration (THC), Maximal Elasticity (E), Mean Elasticity (E), Standard Deviation of Elasticity (E), and Area Ratio were measured. Correlation with post-surgical pathology reports was examined to explore associations between THC, SWE Parameters, and pathology characteristics.
Lesions in patient groups with ER-, PR-, HER2 + , high Ki67, LVI+ , and ALN+ exhibited higher THC, E, and E compared to groups with ER+ , PR+ , HER2-, low Ki67, LVI-, and ALN-. The increase was seen in all grades of IDC-I to -III. THC significantly correlated with S (r = 0.340, P < 0.001), E (r = 0.339, P < 0.001), E (r = 0.201, P = 0.003), and E (r = 0.313, P < 0.001).
US-guided DOT and SWE prove valuable for the quantitative assessment of breast cancer's biological characteristics, with THC positively correlated with E, E, and E.
剪切波弹性成像（SWE）和超声引导漫射光学断层扫描（US-guided DOT）在区分良性和恶性乳腺病变方面显示出潜力。本研究旨在评估 SWE 和 US-guided DOT 在评估乳腺癌生物学特征方面的可行性和相关性。
对 235 例拟在 1 至 3 天内进行手术的乳腺癌患者的 238 个病灶进行了 B 型超声（US）、US-guided DOT 和 SWE 检查。测量了总血红蛋白浓度（THC）、最大弹性（E）、平均弹性（E）、弹性标准差（E）和面积比等参数。通过与术后病理报告的相关性研究，探讨了 THC、SWE 参数与病理特征之间的关系。
ER-、PR-、HER2+、高 Ki67、LVI+和 ALN+患者组的病灶中，THC、E 和 E 高于 ER+、PR+、HER2-、低 Ki67、LVI-和 ALN-患者组。这种增加在所有 IDC-I 至-III 级中都有出现。THC 与 S（r=0.340，P<0.001）、E（r=0.339，P<0.001）、E（r=0.201，P=0.003）和 E（r=0.313，P<0.001）显著相关。
US-guided DOT 和 SWE 可用于定量评估乳腺癌的生物学特征，THC 与 E、E 和 E 呈正相关。
