乳腺癌中剪切波弹性成像与病理特征的相关性分析

Correlation analysis between shear-wave elastography and pathological profiles in breast cancer.

作者信息

Li Junnan, Sun Bo, Li Yanbo, Li Shuang, Wang Jiahui, Zhu Ying, Lu Hong

机构信息

Department of Breast Imaging, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.

The Second Department of Breast Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.

出版信息

Breast Cancer Res Treat. 2023 Jan;197(2):269-276. doi: 10.1007/s10549-022-06804-z. Epub 2022 Nov 14.

DOI:10.1007/s10549-022-06804-z

PMID:36374375

Abstract

PURPOSE

To explore the correlation between shear-wave elastography (SWE) parameters and pathological profiles of invasive breast cancer.

METHODS

A total of 197 invasive breast cancers undergoing preoperative SWE and primary surgical treatment were included. Maximum elastic modulus (Emax), mean elastic modulus (Emean), and elastic modulus standard deviation (Esd) were calculated by SWE. Pathological profile was gold standard according to postoperative pathology. The relationship between SWE parameters and pathological factors were analyzed using univariate and multivariate analysis.

RESULTS

In univariate analysis, large cancers showed significantly higher Emax, Emean and Esd (all P < 0.001). Emax and Esd in the group of histological grade III were higher than those in the group of grade I (both P < 0.05). Invasive lobular carcinomas (ILC) showed higher Emean than invasive ductal carcinoma (IDC) (P < 0.001). Lymphovascular invasion (LVI) group showed higher Emax values than negative group (P < 0.05). Emax, Emean and Esd of the Ki-67 positive group presented higher values than negative group (all P < 0.05). Androgen receptor (AR) positive lesions had lower Esd than AR negative lesions (P < 0.05). In multivariate analysis, invasive size independently influenced Emax (P < 0.001). Invasive size and pathological type both independently influenced Emean (both P < 0.001). Invasive size and AR status were both independently influenced Esd (both P < 0.05).

CONCLUSION

SWE parameters correlated with pathological profiles of invasive breast cancer.In particular, AR positive group showed significantly low Esd than negative group.

摘要

目的

探讨剪切波弹性成像（SWE）参数与浸润性乳腺癌病理特征之间的相关性。

方法

纳入197例术前行SWE检查并接受初次手术治疗的浸润性乳腺癌患者。通过SWE计算最大弹性模量（Emax）、平均弹性模量（Emean）和弹性模量标准差（Esd）。病理特征以术后病理结果为金标准。采用单因素和多因素分析方法分析SWE参数与病理因素之间的关系。

结果

单因素分析显示，肿瘤体积较大者的Emax、Emean和Esd显著更高（均P<0.001）。组织学III级组的Emax和Esd高于I级组（均P<0.05）。浸润性小叶癌（ILC）的Emean高于浸润性导管癌（IDC）（P<0.001）。存在淋巴管浸润（LVI）组的Emax值高于无LVI组（P<0.05）。Ki-67阳性组的Emax、Emean和Esd值均高于阴性组（均P<0.05）。雄激素受体（AR）阳性病变的Esd低于AR阴性病变（P<0.05）。多因素分析显示，肿瘤浸润大小独立影响Emax（P<0.001）。肿瘤浸润大小和病理类型均独立影响Emean（均P<0.001）。肿瘤浸润大小和AR状态均独立影响Esd（均P<0.05）。