Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari, PIN-781101, Assam, India.
Mini Rev Med Chem. 2022;22(17):2244-2259. doi: 10.2174/1389557522666220214092005.
Plant-based drugs have a significant impact on modern therapeutics due to their vast array of pharmacological activities. The integration of herbal plants in the current healthcare system has emerged as a new field of research. It can be used for the identification of novel lead compound candidates for future drug development. Nootkatone is a sesquiterpene derivative and an isolate of grapefruit. Shreds of evidence illustrate that nootkatone targets few molecular mechanisms to exhibit its pharmacological activity and yet needs more exploration. The current review is related to nootkatone, drafted through a literature search using research articles and books from different sources, including Science Direct, Google Scholar, Elsevier, PubMed, and Scopus. It has been reported to possess a wide range of pharmacological activities such as anti-inflammatory, anticancer, antibacterial, hepatoprotective, neuroprotective, and cardioprotective. Although preclinical studies in experimental animal models suggest that nootkatone has therapeutic potential, it is further warranted to evaluate its toxicity and pharmacokinetic parameters before being applied to humans. Hence, in the present review, we have summarized the scientific knowledge on nootkatone with a particular emphasis on its pharmacological properties to encourage researchers for further exploration in preclinical and clinical settings.
由于其广泛的药理活性，植物药对现代治疗学产生了重大影响。将草药植物纳入当前的医疗保健系统已成为一个新的研究领域。它可用于鉴定新型先导化合物候选物，以用于未来的药物开发。诺卡酮是一种倍半萜衍生物，是葡萄柚的一种提取物。有一些证据表明，诺卡酮针对少数分子机制来发挥其药理活性，但仍需要更多的探索。本综述与诺卡酮有关，通过使用来自不同来源（包括 Science Direct、Google Scholar、Elsevier、PubMed 和 Scopus）的研究文章和书籍进行文献检索来起草。据报道，它具有广泛的药理活性，如抗炎、抗癌、抗菌、保肝、神经保护和心脏保护。尽管在实验动物模型中的临床前研究表明诺卡酮具有治疗潜力，但在将其应用于人类之前，仍需要评估其毒性和药代动力学参数。因此，在本综述中，我们总结了关于诺卡酮的科学知识，特别强调了其药理特性，以鼓励研究人员在临床前和临床环境中进一步探索。
