Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia.
Sydney Nano Institute, The University of Sydney, Sydney, NSW 2006, Australia.
Cells. 2022 Jan 24;11(3):388. doi: 10.3390/cells11030388.
Bone is one of the most common metastatic sites among breast cancer (BC) patients. Once bone metastasis is developed, patients' survival and quality of life will be significantly declined. At present, there are limited therapeutic options for BC patients with bone metastasis. Different nanotechnology-based delivery systems have been developed aiming to specifically deliver the therapeutic agents to the bone. The conjugation of targeting agents to nanoparticles can enhance the selective delivery of various payloads to the metastatic bone lesion. The current review highlights promising and emerging advanced nanotechnologies designed for targeted delivery of anticancer therapeutics, contrast agents, photodynamic and photothermal materials to the bone to achieve the goal of treatment, diagnosis, and prevention of BC bone metastasis. A better understanding of various properties of these new therapeutic approaches may open up new landscapes in medicine towards improving the quality of life and overall survival of BC patients who experience bone metastasis.
骨骼是乳腺癌（BC）患者中最常见的转移部位之一。一旦发生骨转移，患者的生存和生活质量将显著下降。目前，针对发生骨转移的 BC 患者，治疗选择有限。不同的基于纳米技术的递药系统已经被开发出来，旨在将治疗药物特异性递送到骨骼。将靶向剂与纳米颗粒偶联可以增强各种有效载荷向转移性骨病变的选择性递药。本综述重点介绍了有前途的新兴先进纳米技术，这些技术旨在将抗癌治疗药物、对比剂、光动力和光热材料靶向递送到骨骼，以实现治疗、诊断和预防 BC 骨转移的目的。更好地了解这些新治疗方法的各种特性，可能会在改善发生骨转移的 BC 患者的生活质量和总体生存率方面为医学带来新的前景。
