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用于治疗耐药性乳腺癌的触发型铁死亡白蛋白 - 生育酚纳米载体

Triggered ferroptotic albumin-tocopherol nanocarriers for treating drug-resistant breast cancer.

作者信息

Gao Qianqian, Liu Tingting, Sun Li, Yao Yongliang, Li Fang, Mao Lingxiang

机构信息

Department of Laboratory Medicine, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, China.

Science and Technology Talents, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, China.

出版信息

Front Oncol. 2024 Oct 23;14:1464909. doi: 10.3389/fonc.2024.1464909. eCollection 2024.

DOI:10.3389/fonc.2024.1464909
PMID:39507754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11538061/
Abstract

Ferroptosis is considered an effective method to overcome drug-resistant tumors. This study aims to use three FDA-approved biological materials, human serum albumin, D-α-tocopherol succinate, and indocyanine green, to construct a novel biocompatible nanomaterial named HTI-NPs, exploring its effect in drug-resistant breast cancer (MCF-7/ADR cells). The research results indicate that HTI-NPs can selectively inhibit the proliferation of MCF-7/ADR cells , accompanied by upregulating transferrin receptor, generating reactive oxygen species, and downregulating glutathione peroxidase 4. Under laser irradiation, HTI-NPs can promote ferroptosis by inhibiting glutathione expression through photodynamic therapy. Notably, HTI-NPs exhibit good inhibitory effects on MCF-7/ADR xenograft tumors . In conclusion, HTI-NPs represent a biocompatible nanomaterial that induces ferroptosis, providing new insights and options for treating drug-resistant breast cancer.

摘要

铁死亡被认为是克服耐药肿瘤的一种有效方法。本研究旨在使用三种经美国食品药品监督管理局（FDA）批准的生物材料，即人血清白蛋白、琥珀酸 D-α-生育酚和吲哚菁绿，构建一种名为 HTI-NPs 的新型生物相容性纳米材料，探索其对耐药乳腺癌（MCF-7/ADR 细胞）的作用。研究结果表明，HTI-NPs 可选择性抑制 MCF-7/ADR 细胞的增殖，同时上调转铁蛋白受体、产生活性氧物种并下调谷胱甘肽过氧化物酶 4。在激光照射下，HTI-NPs 可通过光动力疗法抑制谷胱甘肽表达来促进铁死亡。值得注意的是，HTI-NPs 对 MCF-7/ADR 异种移植肿瘤具有良好的抑制作用。总之，HTI-NPs 是一种诱导铁死亡的生物相容性纳米材料，为治疗耐药乳腺癌提供了新的见解和选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/b5c2125a5b88/fonc-14-1464909-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/085d2a04d5db/fonc-14-1464909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/6ec15bf2fe4b/fonc-14-1464909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/eeb85f0a3cd6/fonc-14-1464909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/96e919c3e88d/fonc-14-1464909-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/b25c7b42b573/fonc-14-1464909-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/4c53a8123815/fonc-14-1464909-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/745493512b5d/fonc-14-1464909-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/413a8d29acaf/fonc-14-1464909-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/b5c2125a5b88/fonc-14-1464909-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/085d2a04d5db/fonc-14-1464909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/6ec15bf2fe4b/fonc-14-1464909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/eeb85f0a3cd6/fonc-14-1464909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/96e919c3e88d/fonc-14-1464909-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/b25c7b42b573/fonc-14-1464909-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/4c53a8123815/fonc-14-1464909-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/745493512b5d/fonc-14-1464909-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/413a8d29acaf/fonc-14-1464909-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdea/11538061/b5c2125a5b88/fonc-14-1464909-g009.jpg

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