Department of Cardiology, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
Department of Clinical Chemistry, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
Cells. 2022 Jan 26;11(3):422. doi: 10.3390/cells11030422.
We aimed to gain insight into the underlying pathophysiology of cardiac dysfunction in obesity patients and the improvement of cardiac function after weight loss.
This is a longitudinal study in which 92 cardiovascular biomarkers were measured by multiplex immunoassays in obesity patients without known cardiovascular disease, before and one year after bariatric surgery.
Out of 100 eligible patients, 72 patients completed the follow-up. A total of 72 (78%) biomarkers changed significantly. The biomarkers with the highest relative changes represented processes linked mainly to insulin resistance and inflammation. In the patients with persistent subclinical cardiac dysfunction, the baseline values of 10 biomarkers were different from values in patients with normalization of cardiac function. Most of these biomarkers were linked to inflammation or atherosclerosis. Finally, a model was developed to investigate the relationship between changes in the biomarkers and persistent subclinical cardiac dysfunction. Seven biomarkers were retained in this model, mainly linked to inflammation, atherosclerosis, and hypercoagulability.
The majority (78%) of cardiovascular biomarkers changed, pointing mainly to modulation of insulin resistance and inflammation. The baseline levels of 10 biomarkers, as well as pre- to post-bariatric surgery changes in seven biomarkers, were related to persistent subclinical cardiac dysfunction after bariatric surgery.
我们旨在深入了解肥胖患者心脏功能障碍的潜在病理生理学机制，以及减肥后心脏功能的改善。
这是一项纵向研究，其中 92 种心血管生物标志物通过多指标免疫分析在无已知心血管疾病的肥胖患者中进行了测量，分别在减肥手术前和一年后进行了测量。
在 100 名符合条件的患者中，有 72 名患者完成了随访。共有 72 种（78%）生物标志物发生了显著变化。相对变化最大的生物标志物主要代表了与胰岛素抵抗和炎症相关的过程。在持续存在亚临床心脏功能障碍的患者中，10 种生物标志物的基线值与心脏功能正常患者的数值不同。这些生物标志物大多与炎症或动脉粥样硬化有关。最后，建立了一个模型来研究生物标志物变化与持续亚临床心脏功能障碍之间的关系。该模型保留了 7 种生物标志物，主要与炎症、动脉粥样硬化和高凝状态有关。
大多数（78%）心血管生物标志物发生了变化，主要指向胰岛素抵抗和炎症的调节。在减肥手术后，10 种生物标志物的基线水平以及 7 种生物标志物在减肥手术前后的变化，与减肥手术后持续存在的亚临床心脏功能障碍有关。
