Macek Piotr, Wieckiewicz Mieszko, Poreba Rafal, Gac Pawel, Bogunia-Kubik Katarzyna, Dratwa Marta, Wojakowska Anna, Mazur Grzegorz, Martynowicz Helena
Department of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Department of Experimental Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.
J Clin Med. 2022 Jan 20;11(3):525. doi: 10.3390/jcm11030525.
Sleep bruxism (SB) is a widespread masticatory muscle activity during sleep and affects approximately 13.2% of the general population. Telomerase reverse transcriptase (TERT) plays a role in preventing the shortening of the telomere. This prospective, observational study aimed to investigate the relationship between single nucleotide polymorphism (SNP) of TERT and the severity of SB and to identify the independent risk factors for SB.
A total of 112 patients were diagnosed by performing one-night polysomnography based on the guidelines of the American Academy of Sleep Medicine. TERT SNP was detected by real-time quantitative polymerase chain reaction (qPCR).
Statistical analysis showed the lack of relationship between the rs2853669 polymorphism of TERT and severity of SB ( > 0.05). However, the study showed that patients with allele T in the 2736100 polymorphism of TERT had a lower score on the phasic bruxism episode index (BEI). Based on the receiver operating characteristic (ROC) curve, the value of phasic BEI was 0.8 for the differential prediction for the presence of allele T in the locus. The sensitivity and specificity were 0.328 and 0.893, respectively. The regression analysis showed that lack of TERT rs2736100 T allele, male gender, and arterial hypertension are the risk factors for the higher value of phasic BEI.
The SNP of the TERT gene affects phasic SB intensity. The absence of TERT rs2736100 T allele, male sex, and arterial hypertension are independent risk factors for phasic SB.
睡眠磨牙症（SB）是一种在睡眠期间广泛存在的咀嚼肌活动，影响着约13.2%的普通人群。端粒酶逆转录酶（TERT）在防止端粒缩短方面发挥作用。这项前瞻性观察研究旨在调查TERT的单核苷酸多态性（SNP）与SB严重程度之间的关系，并确定SB的独立危险因素。
根据美国睡眠医学学会的指南，通过进行一晚的多导睡眠图检查，对总共112名患者进行诊断。通过实时定量聚合酶链反应（qPCR）检测TERT SNP。
统计分析表明，TERT的rs2853669多态性与SB严重程度之间缺乏相关性（>0.05）。然而，研究表明，TERT的2736100多态性中携带等位基因T的患者在发作性磨牙症发作指数（BEI）上得分较低。根据受试者工作特征（ROC）曲线，发作性BEI的值为0.8，用于差异预测该位点等位基因T的存在。敏感性和特异性分别为0.328和0.893。回归分析表明，缺乏TERT rs2736100 T等位基因、男性性别和动脉高血压是发作性BEI值较高的危险因素。
TERT基因的SNP影响发作性SB的强度。缺乏TERT rs2736100 T等位基因、男性性别和动脉高血压是发作性SB的独立危险因素。
