脂肪性胰腺与胰腺癌：一种被忽视的关联？
Fatty Pancreas and Pancreatic Cancer: An Overlooked Association?
作者信息
Khoury Tawfik, Sbeit Wisam
机构信息
Department of Gastroenterology, Galilee Medical Center, Nahariya 22100, Israel.
Faculty of Medicine in the Galilee, Bar-Ilan University, Safed 5290002, Israel.
出版信息
J Clin Med. 2022 Jan 30;11(3):763. doi: 10.3390/jcm11030763.
BACKGROUND
fatty pancreas (FP) is an old observation, but a new disease with clinical implications and several associated comorbid conditions, ranging from mild to life-threatening diseases. Herein, we aimed to assess the association between FP and pancreatic cancer (PC) development.
METHODS
we performed a retrospective cross-sectional study including all patients who underwent endoscopic ultrasound (EUS) for hepatobiliary indications. The study cohort was divided into patients with and without PC. Univariate and multivariate analysis were used to assess the association of several parameters with PC.
RESULTS
overall, 519 patients were included in the study. Of them, 48 had PC (PC group), and 471 did not (non-PC group). In univariate analysis, age (OR 1.04, 95% CI 1.01-1.07, = 0.004), congestive heart failure (CHF) (OR 3.89, 95% CI 1.72-8.79, = 0.001), ischemic heart disease (IHD) (OR 3.36, 95% CI 1.59-7.05, = 0.001), hypertension (OR 2.42, 95% CI 1.33-4.41, = 0.004) and fatty pancreas (FP) (OR 2.62, 95% CI 1.23-5.57, = 0.01) were significantly associated with PC. In multivariate logistic regression analysis, only FP kept its association (OR 2.35, 95% CI 1.04-5.33, = 0.04).
CONCLUSION
FP was significantly associated with PC. A follow-up plan should be considered for individuals with FP.
背景
脂肪性胰腺（FP）虽是一个早已被观察到的现象，但却是一种具有临床意义且伴有多种相关合并症的新疾病，这些合并症涵盖了从轻度到危及生命的各种疾病。在此，我们旨在评估FP与胰腺癌（PC）发生之间的关联。
方法
我们进行了一项回顾性横断面研究，纳入了所有因肝胆疾病指征接受内镜超声检查（EUS）的患者。研究队列被分为患有PC和未患有PC的患者。采用单因素和多因素分析来评估多个参数与PC的关联。
结果
总体而言，519名患者被纳入研究。其中，48例患有PC（PC组），471例未患PC（非PC组）。在单因素分析中，年龄（比值比[OR] 1.04，95%置信区间[CI] 1.01 - 1.07，P = 0.004）、充血性心力衰竭（CHF）（OR 3.89，95% CI 1.72 - 8.79，P = 0.001）、缺血性心脏病（IHD）（OR 3.36，95% CI 1.59 - 7.05，P = 0.001）、高血压（OR 2.42，95% CI 1.33 - 4.41，P = 0.004）和脂肪性胰腺（FP）（OR 2.62，95% CI 1.23 - 5.57，P = 0.01）与PC显著相关。在多因素逻辑回归分析中，只有FP保持其相关性（OR 2.35，95% CI 1.04 - 5.33，P = 0.04）。
结论
FP与PC显著相关。对于患有FP的个体，应考虑制定随访计划。
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