Lipp Mónika, Tarján Dorottya, Lee Jimin, Zolcsák Ádám, Szalai Eszter, Teutsch Brigitta, Faluhelyi Nándor, Erőss Bálint, Hegyi Péter, Mikó Alexandra
Institute of Pancreatic Diseases, Semmelweis University, 1083 Budapest, Hungary.
Centre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.
Cancers (Basel). 2023 Oct 7;15(19):4876. doi: 10.3390/cancers15194876.
Pancreatic cancer (PC) is one of the most lethal cancers worldwide. Recently, fatty pancreas (FP) has been studied thoroughly, and although its relationship to PC is not fully understood, FP is suspected to contribute to the development of PC. We aimed to assess the association between PC and FP by conducting a systematic review and meta-analysis. We systematically searched three databases, MEDLINE, Embase, and CENTRAL, on 21 October 2022. Case-control and cross-sectional studies reporting on patients where the intra-pancreatic fat deposition was determined by modern radiology or histology were included. As main outcome parameters, FP in patients with and without PC and PC in patients with and without FP were measured. Proportion and odds ratio (OR) with a 95% confidence interval (CI) were used for effect size measure. PC among patients with FP was 32% (OR 1.32; 95% CI 0.42-4.16). However, the probability of having FP among patients with PC was more than six times higher (OR 6.13; 95% CI 2.61-14.42) than in patients without PC, whereas the proportion of FP among patients with PC was 0.62 (95% CI 0.42-0.79). Patients identified with FP are at risk of developing PC. Proper screening and follow-up of patients with FP may be recommended.
胰腺癌（PC）是全球最致命的癌症之一。最近，脂肪性胰腺（FP）已得到充分研究，尽管其与PC的关系尚未完全明确，但怀疑FP会促使PC的发生。我们旨在通过进行系统评价和荟萃分析来评估PC与FP之间的关联。2022年10月21日，我们系统检索了三个数据库，即医学文献数据库（MEDLINE）、荷兰医学文摘数据库（Embase）和考克兰系统评价数据库（CENTRAL）。纳入了通过现代放射学或组织学确定胰腺内脂肪沉积情况的患者的病例对照研究和横断面研究。作为主要结局参数，测量了有和没有PC的患者中的FP以及有和没有FP的患者中的PC。效应量测量采用比例和比值比（OR）以及95%置信区间（CI）。FP患者中PC的比例为32%（OR 1.32；95% CI 0.42 - 4.16）。然而，PC患者中有FP的概率比无PC患者高出六倍多（OR 6.13；95% CI 2.61 - 14.42），而PC患者中FP的比例为0.62（95% CI 0.42 - 0.79）。确诊为FP的患者有患PC的风险。可能建议对FP患者进行适当的筛查和随访。
