Lemmer Peter, Manka Paul, Best Jan, Kahraman Alisan, Kälsch Julia, Vilchez-Vargas Ramiro, Link Alexander, Chiang Hsin, Gerken Guido, Canbay Ali, Bechmann Lars P, Sydor Svenja
Department of Internal Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, 44892 Bochum, Germany.
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.
J Clin Med. 2022 Feb 8;11(3):890. doi: 10.3390/jcm11030890.
Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) have emerged as leading causes of chronic liver diseases worldwide. ALD and NAFLD share several pathophysiological patterns as well as histological features, while clinically, they are distinguished by the amount of alcohol consumed daily. However, NAFLD coexists with moderate alcohol consumption in a growing proportion of the population. Here, we investigated the effects of moderate alcohol consumption on liver injury, lipid metabolism, and gut microbiota in 30 NAFLD-patients. We anonymously assessed drinking habits, applying the AUDIT- and CAGE-questionnaires and compared subgroups of abstainers vs. low to harmful alcohol consumers (AUDIT) and Cage 0-1 vs. Cage 2-4. Patients who did not drink any alcohol had lower levels of γGT, ALT, triglycerides, and total cholesterol. While the abundance of , , , and was higher in the low to harmful alcohol drinking cohort, the abundance of was higher in the abstainers. Our study suggests that even moderate alcohol consumption has an impact on the liver and lipid metabolism, as well as on the composition of gut microbiota.
酒精性肝病（ALD）和非酒精性脂肪性肝病（NAFLD）已成为全球慢性肝病的主要病因。ALD和NAFLD具有多种病理生理模式以及组织学特征，而在临床上，它们通过每日饮酒量来区分。然而，在越来越多的人群中，NAFLD与适度饮酒并存。在此，我们研究了适度饮酒对30例NAFLD患者肝损伤、脂质代谢和肠道微生物群的影响。我们使用AUDIT问卷和CAGE问卷对饮酒习惯进行了匿名评估，并比较了戒酒者与低度至有害饮酒者亚组（AUDIT）以及Cage 0 - 1与Cage 2 - 4亚组。不饮酒的患者γGT、ALT、甘油三酯和总胆固醇水平较低。虽然在低度至有害饮酒队列中，[此处原文缺失具体菌种名称]、[此处原文缺失具体菌种名称]、[此处原文缺失具体菌种名称]和[此处原文缺失具体菌种名称]的丰度较高，但在戒酒者中，[此处原文缺失具体菌种名称]的丰度较高。我们的研究表明，即使是适度饮酒也会对肝脏、脂质代谢以及肠道微生物群的组成产生影响。
