Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.
Laboratory of Veterinary Physiology, College of Veterinary Medicine, Jeju National University, Jeju-si 63243, Korea.
Int J Mol Sci. 2022 Jan 29;23(3):1581. doi: 10.3390/ijms23031581.
There is growing concern regarding the health and safety issues of endocrine-disrupting chemicals (EDCs). Long-term exposure to EDCs has serious adverse health effects through both hormone-direct and hormone-indirect ways. Accordingly, some EDCs can be a pathogen and an inducer to the susceptibility of disease, even if they have a very low affinity on the estrogen receptor, or no estrogenic effect. Endoplasmic reticulum (ER) stress recently attracted attention in this research area. Because ER and ER stress could be key regulators of the EDC's adverse effects, such as the malfunction of the organ, as well as the death, apoptosis, and proliferation of a cell. In this review, we focused on finding evidence which shows that EDCs could be a trigger for ER stress and provide specific examples of EDCs, which are known to cause ER stress currently.
人们越来越关注内分泌干扰化学物质（EDCs）的健康和安全问题。长期暴露于 EDCs 会通过激素直接和间接途径对健康造成严重的不良影响。因此，一些 EDCs 可能是疾病易感性的病原体和诱导物，即使它们对雌激素受体的亲和力非常低，或者没有雌激素作用。内质网（ER）应激最近在这个研究领域引起了关注。因为 ER 和 ER 应激可能是 EDC 不良影响的关键调节剂，如器官功能障碍，以及细胞的死亡、凋亡和增殖。在这篇综述中，我们专注于寻找证据表明 EDCs 可能是 ER 应激的触发因素，并提供目前已知会引起 ER 应激的 EDCs 的具体例子。
