St. Catherine Specialty Hospital, 10000 Zagreb, Croatia.
Department of Oral Surgery, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Int J Mol Sci. 2022 Jan 31;23(3):1662. doi: 10.3390/ijms23031662.
Application of mesenchymal stem cells (MSC) in regenerative therapeutic procedures is becoming an increasingly important topic in medicine. Since the first isolation of dental tissue-derived MSC, there has been an intense investigation on the characteristics and potentials of these cells in regenerative dentistry. Their multidifferentiation potential, self-renewal capacity, and easy accessibility give them a key role in stem cell-based therapy. So far, several different dental stem cell types have been discovered and their potential usage is found in most of the major dental medicine branches. These cells are also researched in multiple fields of medicine for the treatment of degenerative and inflammatory diseases. In this review, we summarized dental MSC sources and analyzed their treatment modalities with particular emphasis on temporomandibular joint osteoarthritis (TMJ OA).
间充质干细胞（MSC）在再生治疗中的应用正成为医学领域日益重要的课题。自首次分离出牙组织来源的 MSC 以来，人们对这些细胞在再生牙科中的特性和潜力进行了深入研究。它们的多向分化潜能、自我更新能力和易于获取性使它们在基于干细胞的治疗中发挥关键作用。到目前为止，已经发现了几种不同的牙源性干细胞类型，它们在大多数主要的牙科医学分支中的潜在用途已经被发现。这些细胞也在医学的多个领域中被研究用于治疗退行性和炎症性疾病。在这篇综述中，我们总结了间充质干细胞的来源，并分析了它们的治疗方式，特别强调了颞下颌关节骨关节炎（TMJ OA）。
