Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio y Plan de Ayala S/N Col. Santo Tomás Alc. Miguel Hidalgo, Ciudad de México 11340, Mexico.
Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio y Plan de Ayala S/N Col. Santo Tomás Alc. Miguel Hidalgo, Ciudad de México 11340, Mexico.
Molecules. 2022 Jan 20;27(3):655. doi: 10.3390/molecules27030655.
Extracts of L. (commonly called Rosselle or "Jamaica flower" in Mexico) have been shown to have antibiotic and antivirulence properties in several bacteria. Here, an organic extract of L. is shown to inhibit motility in serovars Typhi and Typhimurium. The compound responsible for this effect was purified and found to be the hibiscus acid. When tested, this compound also inhibited motility and reduced the secretion of both flagellin and type III secretion effectors. Purified hibiscus acid was not toxic in tissue-cultured eukaryotic cells, and it was able to reduce the invasion of Typhimurium in epithelial cells. Initial steps to understand its mode of action showed it might affect membrane proton balance.
L.（通常在墨西哥被称为罗塞拉或“牙买加花”）的提取物已被证明对几种细菌具有抗生素和抗毒力特性。在这里，L.的有机提取物被证明可抑制伤寒和肠炎沙门氏菌血清型的运动性。负责此效果的化合物已被纯化，并被鉴定为芙蓉酸。当测试时，该化合物还抑制运动并减少鞭毛蛋白和 III 型分泌效应物的分泌。纯化的芙蓉酸在组织培养的真核细胞中没有毒性，并且能够减少肠炎沙门氏菌在肠上皮细胞中的入侵。了解其作用机制的初步步骤表明，它可能会影响膜质子平衡。
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