Pene P, Mojon M, Garin J P, Coulaud J P, Rossignol J F
Am J Trop Med Hyg. 1982 Mar;31(2):263-6. doi: 10.4269/ajtmh.1982.31.263.
A new anthelmintic drug, albendazole, has been tested in a multicenter double-blind placebo controlled study in 392 patients from France and West Africa in children and adults with single or mixed infections caused by roundworms, hookworms, whipworms, threadworms and tapeworms. All patients were closely observed before and after treatment for clinical side effects, hematological or clinical blood chemical changes. Fecal samples obtained before, and 7 days and 21 days after treatment were examined using a concentration technic (Ritchie), a coproculture (Harada-Mori) and an egg count (Kato). Following a single dose of 400 mg in adults, cure rates of 96% in ascaridiasis, 96% in ancylostomiasis caused by dose of 400 mg in adults, cure rates of 96% in ascaridiasis, 96% in ancylostomiasis caused by Ancylostoma duodenale, 90% in ancylostomiasis caused by Necator americanus and 76% in trichuriasis were recorded. About 48% of the patients infected by Strongyloides stercoralis were cured following administration of 400 mg per day for 3 consecutive days. The efficacy of half of the adult dose (200 mg) was much lower in children. None of the patients who received placebo were cured. The drug did not produce any significant side effects and approximately the same numbers were reported in the albendazole and the placebo groups. No variations of the hematology and clinical blood chemistry values were recorded.
一种新型驱虫药阿苯达唑，在一项多中心双盲安慰剂对照研究中对来自法国和西非的392名儿童及成人患者进行了测试，这些患者患有由蛔虫、钩虫、鞭虫、蛲虫和绦虫引起的单一或混合感染。所有患者在治疗前后均被密切观察临床副作用、血液学或临床血液化学变化。治疗前、治疗后7天和21天采集的粪便样本，采用浓缩技术（里奇法）、粪便培养（原田-森氏法）和虫卵计数（加藤法）进行检测。成人单次服用400毫克后，蛔虫病治愈率为96%，十二指肠钩虫引起的钩虫病治愈率为96%，美洲板口线虫引起的钩虫病治愈率为90%，鞭虫病治愈率为76%。连续3天每天服用400毫克后，约48%感染粪类圆线虫的患者被治愈。儿童服用成人剂量一半（200毫克）的疗效要低得多。接受安慰剂的患者无一治愈。该药物未产生任何显著副作用，阿苯达唑组和安慰剂组报告的副作用数量大致相同。血液学和临床血液化学值未出现变化。
