College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
Molecules. 2022 Jan 22;27(3):722. doi: 10.3390/molecules27030722.
Four new benzoylamide derivatives, lepidiumamide B-E (-), were isolated from the seeds of Willd. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury.
从野芝麻种子中分离得到四个新的苯甲酰胺衍生物，即 Lepidiumamide B-E（-）。通过 MS 和 NMR 分析的组合确定了它们的结构。所有化合物均在体外评估了它们对脂多糖（LPS）诱导的 NRK-52e 细胞损伤的保护作用。这些化合物表现出显著的保护活性，并通过 Nrf2/Keap1 途径改善了 LPS 诱导的 NRK52e 细胞。这些活性化合物的发现对于预防和治疗肾损伤很重要。
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