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[一种来自独行菜种子的新型苯乙酰胺]

[A new phenylacetamide from the seeds of Lepidium apetalum Willd].

作者信息

Meng Li, Zheng Xiao-ke, Zhang Zhi-guang, Zhang Jing-ke, Zhao Xuan, Yang Yan-yun, Wang Xiao-lan, Kuang Hai-xue, Feng Wei-sheng

出版信息

Yao Xue Xue Bao. 2016 Dec;51(12):1881-4.

PMID:29908559
Abstract

The chemical constituents of the seeds of Lepidium apetalum Willd. were investigated using chromatographic methods, including Diaion HP-20, Toyopearl HW-40, MCI Gel CHP-20, ODS, silica gel chromatography and semi-preparative-HPLC. Three compounds were isolated and their structures were elucidated by spectral data and physicochemical properties, which were identified as lepidiumamide A (1), cis-desulfoglucotropaeolin(2), trans-desulfoglucotropaeolin (3). Among those, compound 1 is a new phenylacetamide, compound 2 and 3 were isolated from this plant for the first time, and their configurations were also identified for the first time.

摘要

采用Diaion HP - 20、Toyopearl HW - 40、MCI Gel CHP - 20、ODS、硅胶柱色谱以及半制备高效液相色谱等色谱方法，对独行菜种子的化学成分进行了研究。分离得到了3个化合物，并通过光谱数据和理化性质对其结构进行了鉴定，分别鉴定为独行菜酰胺A（1）、顺式脱硫葡萄糖异硫氰酸酯（2）、反式脱硫葡萄糖异硫氰酸酯（3）。其中，化合物1为新的苯乙酰胺类化合物，化合物2和3首次从该植物中分离得到，且其构型也首次被鉴定。

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