从独行菜种子中分离出的新型生物活性黄酮苷

New bioactive flavonoid glycosides isolated from the seeds of Lepidium apetalum Willd.

作者信息

Shi Pingping, Chao Liping, Wang Tingtxing, Liu Erwei, Han Lifeng, Zong Qi, Li Xiaoxia, Zhang Yi, Wang Tao

机构信息

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.

Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China.

出版信息

Fitoterapia. 2015 Jun;103:197-205. doi: 10.1016/j.fitote.2015.04.007. Epub 2015 Apr 11.

DOI:10.1016/j.fitote.2015.04.007

PMID:25869847

Abstract

Ten flavonoid glycosides, apetalumosides A (1), B1-B7 (2-8), and C (9), quercetin 3-O-(2,6-di-O-β-D-glucopyranosyl)-β-D-glucopyranoside (10), were obtained from the seeds of Lepidium apetalum Willd. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, NMR, and HRESI-TOF-MS). 1-9 were new isolates. The NMR data for 10 was reported here for the first time. On the other hand, activity screening results showed that 1-3 and 10 had triglyceride accumulation inhibitory effects in HepG2 cells. Preliminary structure-activity relationship study revealed that 7-hydroxyl group is an essential moiety.

摘要

从独行菜种子中获得了十种黄酮苷，即无瓣岩白菜苷A（1）、B1 - B7（2 - 8）和C（9）、槲皮素3 - O -（2,6 - 二 - O - β - D - 吡喃葡萄糖基）- β - D - 吡喃葡萄糖苷（10）。通过化学和光谱方法（紫外、红外、核磁共振和高分辨电喷雾电离飞行时间质谱）阐明了它们的结构。1 - 9为新分离物。10的核磁共振数据在此首次报道。另一方面，活性筛选结果表明，1 - 3和10对HepG2细胞具有甘油三酯积累抑制作用。初步的构效关系研究表明，7 - 羟基是一个必需基团。