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用铁蛋白或牛血清白蛋白经口免疫后C3H/HeJ小鼠中的IgA系膜沉积物

IgA mesangial deposits in C3H/HeJ mice after oral immunization with ferritin or bovine serum albumin.

作者信息

Genin C, Laurent B, Sabatier J C, Colon S, Berthoux F C

出版信息

Clin Exp Immunol. 1986 Feb;63(2):385-94.

PMID:3516467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577390/
Abstract

In order to study an experimental model of IgA nephropathy, C3H/HeJ mice which are high IgA responders were strongly immunized orally with ferritin and compared to syngeneic C3H/eB. C3H/HeJ exhibited a significant increase of total IgA level in the serum and of IgA deposits in the mesangium. However the low level of IgA antibody to ferritin detected in the serum and the unsuccessful search for ferritin and antibody to ferritin in the glomeruli suggest that strong oral immunization of C3H/HeJ mice leads to high level of non specific IgA in the serum and deposition of IgA in the kidney.

摘要

为了研究IgA肾病的实验模型，用铁蛋白对高IgA反应性的C3H/HeJ小鼠进行口服强免疫，并与同基因的C3H/eB小鼠进行比较。C3H/HeJ小鼠血清中总IgA水平显著升高，系膜中IgA沉积物也显著增加。然而，血清中检测到的针对铁蛋白的低水平IgA抗体，以及在肾小球中未能找到铁蛋白和抗铁蛋白抗体，表明对C3H/HeJ小鼠进行口服强免疫会导致血清中高水平的非特异性IgA以及IgA在肾脏中的沉积。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe45/1577390/e22e0878dd71/clinexpimmunol00125-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe45/1577390/721233b99729/clinexpimmunol00125-0131-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe45/1577390/e22e0878dd71/clinexpimmunol00125-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe45/1577390/721233b99729/clinexpimmunol00125-0131-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe45/1577390/e22e0878dd71/clinexpimmunol00125-0132-a.jpg

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引用本文的文献

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本文引用的文献

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Improvements in epoxy resin embedding methods.环氧树脂包埋方法的改进。
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In vivo experiments involving secretory component in the rat hepatic transfer of polymeric IgA from blood into bile.在大鼠体内进行的实验，涉及分泌成分在聚合物IgA从血液向胆汁的肝脏转运过程中的作用。
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Mice refractory to lipopolysaccharide manifest high immunoglobulin A responses to orally administered antigen.对脂多糖耐受的小鼠对口服抗原表现出高免疫球蛋白A反应。
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Detection and characterization of circulating and glomerular immune complexes in experimental IgA nephropathy.实验性IgA肾病中循环免疫复合物和肾小球免疫复合物的检测与特征分析
Immunology. 1990 Jul;70(3):296-302.
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Clin Exp Immunol. 1982 Mar;47(3):527-34.
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Detection of monomeric and polymeric IgA containing immune complexes in serum and kidney from patients with alcoholic liver disease.酒精性肝病患者血清和肾脏中含免疫复合物的单体和聚合IgA的检测。
Clin Exp Immunol. 1982 Feb;47(2):327-35.
7
Deposition of idiotype-anti-idiotype immune complexes in renal glomeruli after polyclonal B cell activation.多克隆B细胞活化后肾小球中独特型-抗独特型免疫复合物的沉积。
J Exp Med. 1982 May 1;155(5):1385-99. doi: 10.1084/jem.155.5.1385.
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Prevalence of IgA2 deposits in IgA nephropathies: a clue to their pathogenesis.IgA肾病中IgA2沉积物的患病率：其发病机制的线索
N Engl J Med. 1980 Dec 4;303(23):1343-6. doi: 10.1056/NEJM198012043032306.
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Enzyme immunoassay ELISA and EMIT.酶免疫测定法（ELISA）和酶放大免疫测定技术（EMIT）。
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