IgA肾病：通过游离分泌成分的体外结合对系膜沉积物的聚合性质进行表征。
IgA nephropathy: characterization of the polymeric nature of mesangial deposits by in vitro binding of free secretory component.
作者信息
Bene M C, Faure G, Duheille J
出版信息
Clin Exp Immunol. 1982 Mar;47(3):527-34.
Abstract
IgA nephropathy, as Berger defined it, is characterized by mesangial deposits of IgA, which are easily visualized by immunofluorescence on kidney biopsies. The structure (mono- or dimeric) of these IgA has not been clearly defined so far. Fifteen renal biopsies were studied to find out whether these IgA are serum monomers, or are polymers from a different origin. This was done by tissue fixation in vitro of free secretory component, which was then visualized by immunofluorescence (IF). In all 15 cases, the IgA deposits were shown to lack bound secretory component, but were able to bind, specifically, with the free secretory component. The presence of J chain in these deposits was also evidenced by indirect IF. These findings favour the hypothesis that these immunoglobulins are polymeric.
摘要
如伯杰所定义的，IgA肾病的特征是IgA在系膜沉积，通过肾脏活检的免疫荧光很容易观察到。到目前为止，这些IgA的结构（单体或二聚体）尚未明确界定。研究了15份肾活检样本，以确定这些IgA是血清单体，还是来自不同来源的聚合物。这是通过体外固定游离分泌成分的组织来完成的，然后通过免疫荧光（IF）进行观察。在所有15例病例中，IgA沉积物均显示缺乏结合的分泌成分，但能够与游离分泌成分特异性结合。间接免疫荧光也证实了这些沉积物中存在J链。这些发现支持了这些免疫球蛋白是聚合物的假说。
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