肥胖和 2 型糖尿病的代谢后果：平衡基因与环境，实现个性化护理。
Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care.
机构信息
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
出版信息
Cell. 2021 Mar 18;184(6):1530-1544. doi: 10.1016/j.cell.2021.02.012. Epub 2021 Mar 5.
The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases.
几十年来，2 型糖尿病和肥胖症的患病率显著上升，预计随着人口老龄化和久坐不动的人群不断增加，这一趋势还将进一步加剧。全球医疗保健系统面临的压力预计将是巨大的。本综述探讨了与影响代谢的遗传和环境因素相关的最新研究和新兴观点。重点介绍了转化研究和临床应用，包括 COVID-19 大流行的影响。展望未来，有必要制定个性化的预防、管理和护理策略，以改善健康结果并减轻这些代谢性疾病的影响。
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