偏头痛患者颈部疼痛的患病率：一项系统评价与荟萃分析。

Prevalence of neck pain in migraine: A systematic review and meta-analysis.

作者信息

Al-Khazali Haidar Muhsen, Younis Samaira, Al-Sayegh Zainab, Ashina Sait, Ashina Messoud, Schytz Henrik W

机构信息

Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Comprehensive Headache Center, Departments of Neurology and Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

出版信息

Cephalalgia. 2022 Jun;42(7):663-673. doi: 10.1177/03331024211068073. Epub 2022 Feb 15.

DOI:10.1177/03331024211068073

PMID:35166137

Abstract

BACKGROUND

Neck pain is a frequent complaint among patients with migraine and seems to be correlated with the headache frequency. Neck pain is more common in patients with chronic migraine compared to episodic migraine. However, prevalence of neck pain in patients with migraine varies among studies.

OBJECTIVE

To estimate the prevalence of neck pain in patients with migraine and non-headache controls in observational studies.

METHODS

A systematic literature search on PubMed and Embase was conducted to identify studies reporting prevalence of neck pain in migraine patients. This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data was extracted by two independent investigators and results were pooled using random-effects meta-analysis. The protocol was registered with PROSPERO (CRD42021264898).

RESULTS

The search identified 2490 citations of which 30 contained relevant original population based and clinic-based data. Among these, 24 studies provided data eligible for the analysis. The meta-analysis for clinic-based studies demonstrated that the pooled relative frequency of neck pain was 77.0% (95% CI: 69.0-86.4) in the migraine group and 23.2% (95% CI:18.6-28.5) in the non-headache control group. Neck pain was more frequent in patients with chronic migraine (87.0%, 95% CI: 77.0-93.0) compared to episodic migraine (77.0%, 95% CI: 69.0-84.0). Neck pain was 12 times more prevalent in migraine patients compared to non-headache controls and two times more prevalent in patients with chronic migraine compared to episodic migraine. The calculated heterogeneity (I values) ranged from 61.3% to 72.0%.

CONCLUSION

Neck pain is a frequent complaint among patients with migraine. The heterogeneity among the studies emphasize important aspects to consider in future research of neck pain in migraine to improve our understanding of the driving mechanisms of neck pain in a major group of migraine patients.

摘要

背景

颈部疼痛是偏头痛患者常见的主诉，且似乎与头痛频率相关。与发作性偏头痛患者相比，颈部疼痛在慢性偏头痛患者中更为常见。然而，偏头痛患者颈部疼痛的患病率在不同研究中有所差异。

目的

在观察性研究中估计偏头痛患者和非头痛对照者颈部疼痛的患病率。

方法

在PubMed和Embase上进行系统文献检索，以确定报告偏头痛患者颈部疼痛患病率的研究。本综述遵循系统评价和Meta分析的首选报告项目指南进行。数据由两名独立研究人员提取，并使用随机效应Meta分析汇总结果。该方案已在国际前瞻性系统评价注册库（PROSPERO，注册号：CRD42021264898）注册。

结果

检索共识别出2490条引用，其中30篇包含基于人群和基于临床的相关原始数据。其中，24项研究提供了符合分析条件的数据。基于临床研究的Meta分析表明，偏头痛组颈部疼痛的合并相对频率为77.0%（95%CI：69.0 - 86.4），非头痛对照组为23.2%（95%CI：18.6 - 28.5）。与发作性偏头痛（77.0%，95%CI：69.0 - 84.0）相比，慢性偏头痛患者颈部疼痛更为常见（87.0%，95%CI：77.0 - 93.0）。偏头痛患者颈部疼痛的患病率是非头痛对照者的12倍，慢性偏头痛患者颈部疼痛的患病率是发作性偏头痛患者的2倍。计算出的异质性（I值）范围为61.3%至72.0%。