Munford Maxwell J, Stoddart Jennifer C, Liddle Alexander D, Cobb Justin P, Jeffers Jonathan R T
The Biomechanics Group, Department of Mechanical Engineering, Imperial College London, London, UK.
The MSk Lab, Department of Surgery and Cancer, Imperial College London, London, UK.
Bone Joint Res. 2022 Feb;11(2):91-101. doi: 10.1302/2046-3758.112.BJR-2021-0304.R1.
Unicompartmental and total knee arthroplasty (UKA and TKA) are successful treatments for osteoarthritis, but the solid metal implants disrupt the natural distribution of stress and strain which can lead to bone loss over time. This generates problems if the implant needs to be revised. This study investigates whether titanium lattice UKA and TKA implants can maintain natural load transfer in the proximal tibia.
In a cadaveric model, UKA and TKA procedures were performed on eight fresh-frozen knee specimens, using conventional (solid) and titanium lattice tibial implants. Stress at the bone-implant interfaces were measured and compared to the native knee.
Titanium lattice implants were able to restore the mechanical environment of the native tibia for both UKA and TKA designs. Maximum stress at the bone-implant interface ranged from 1.2 MPa to 3.3 MPa compared with 1.3 MPa to 2.7 MPa for the native tibia. The conventional solid UKA and TKA implants reduced the maximum stress in the bone by a factor of 10 and caused > 70% of bone surface area to be underloaded compared to the native tibia.
Titanium lattice implants maintained the natural mechanical loading in the proximal tibia after UKA and TKA, but conventional solid implants did not. This is an exciting first step towards implants that maintain bone health, but such implants also have to meet fatigue and micromotion criteria to be clinically viable. Cite this article: 2022;11(2):91-101.
单髁膝关节置换术和全膝关节置换术(UKA和TKA)是治疗骨关节炎的成功方法,但实心金属植入物会破坏应力和应变的自然分布,随着时间的推移可能导致骨质流失。如果需要翻修植入物,这会产生问题。本研究调查钛晶格UKA和TKA植入物是否能维持胫骨近端的自然负荷传递。
在一个尸体模型中,对八个新鲜冷冻的膝关节标本进行UKA和TKA手术,使用传统(实心)和钛晶格胫骨植入物。测量骨-植入物界面的应力,并与天然膝关节进行比较。
对于UKA和TKA设计,钛晶格植入物能够恢复天然胫骨的力学环境。骨-植入物界面的最大应力范围为1.2MPa至3.3MPa,而天然胫骨为1.3MPa至2.7MPa。与天然胫骨相比,传统的实心UKA和TKA植入物使骨中的最大应力降低了10倍,并导致超过70%的骨表面积负荷不足。
UKA和TKA术后,钛晶格植入物维持了胫骨近端的自然机械负荷,但传统的实心植入物则没有。这是朝着维持骨骼健康的植入物迈出的令人兴奋的第一步,但此类植入物还必须满足疲劳和微动标准才能在临床上可行。引用本文:2022;11(2):91-101。