Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, NY, 10027, USA.
Doctoral Program in Neurobiology and Behavior, Columbia University, New York, 10027, NY, USA.
Nat Commun. 2018 Jun 21;9(1):2423. doi: 10.1038/s41467-018-04847-9.
The hippocampus plays a vital role in various aspects of cognition including both memory and spatial navigation. To understand electrophysiologically how the hippocampus supports these processes, we recorded intracranial electroencephalographic activity from 46 neurosurgical patients as they performed a spatial memory task. We measure signals from multiple brain regions, including both left and right hippocampi, and we use spectral analysis to identify oscillatory patterns related to memory encoding and navigation. We show that in the left but not right hippocampus, the amplitude of oscillations in the 1-3-Hz "low theta" band increases when viewing subsequently remembered object-location pairs. In contrast, in the right but not left hippocampus, low-theta activity increases during periods of navigation. The frequencies of these hippocampal signals are slower than task-related signals in the neocortex. These results suggest that the human brain includes multiple lateralized oscillatory networks that support different aspects of cognition.
海马体在包括记忆和空间导航在内的各种认知方面发挥着至关重要的作用。为了在电生理水平上理解海马体如何支持这些过程，我们在 46 名接受神经外科手术的患者进行空间记忆任务时记录了他们的颅内脑电图活动。我们测量了来自多个脑区的信号，包括左、右海马体，并使用频谱分析来识别与记忆编码和导航相关的振荡模式。我们发现，在左海马体中，但不在右海马体中，当观看随后记住的物体-位置对时，1-3 赫兹的“低 theta”波段的振荡幅度会增加。相比之下，在右海马体中，但不在左海马体中，低频 theta 活动会在导航期间增加。这些海马体信号的频率比新皮层中与任务相关的信号慢。这些结果表明，人类大脑包括多个偏侧化的振荡网络，这些网络支持认知的不同方面。
