Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Graduate School of Medicine, Osaka University, Osaka, Japan.
Sci Rep. 2022 Feb 15;12(1):2546. doi: 10.1038/s41598-022-06401-6.
For radiological diagnosis and radionuclide therapy, X-ray and gamma-ray imaging technologies are essential. Single-photon emission tomography (SPECT) and positron emission tomography (PET) play essential roles in radiological diagnosis, such as the early detection of tumors. Radionuclide therapy is also rapidly developing with the use of these modalities. Nevertheless, a limited number of radioactive tracers are imaged owing to the limitations of the imaging devices. In a previous study, we developed a hybrid Compton camera that conducts simultaneous Compton and pinhole imaging within a single system. In this study, we developed a system that simultaneously realizes three modalities: Compton, pinhole, and PET imaging in 3D space using multiple hybrid Compton cameras. We achieved the simultaneous imaging of Cs-137 (Compton mode targeting 662 keV), Na-22 (PET mode targeting 511 keV), and Am-241 (pinhole mode targeting 60 keV) within the same field of view. In addition, the imaging of Ga-67 and In-111, which are used in various diagnostic scenarios, was conducted. We also verified that the 3D distribution of the At-211 tracer inside a mouse could be imaged using the pinhole mode.
对于放射诊断和放射性核素治疗，X 射线和伽马射线成像技术是必不可少的。单光子发射断层扫描（SPECT）和正电子发射断层扫描（PET）在放射诊断中发挥着重要作用，例如肿瘤的早期检测。放射性核素治疗也在迅速发展，这些模式得到了应用。然而，由于成像设备的限制，只有有限数量的放射性示踪剂可以成像。在之前的一项研究中，我们开发了一种混合康普顿相机，可以在单个系统中同时进行康普顿和针孔成像。在这项研究中，我们开发了一种系统，该系统使用多个混合康普顿相机在 3D 空间中同时实现三种模式：康普顿、针孔和 PET 成像。我们在同一视野内同时实现了 Cs-137（康普顿模式，针对 662keV）、Na-22（PET 模式，针对 511keV）和 Am-241（针孔模式，针对 60keV）的成像。此外，还进行了 Ga-67 和 In-111 的成像，这些示踪剂用于各种诊断场景。我们还验证了可以使用针孔模式对小鼠体内的 At-211 示踪剂进行 3D 分布成像。
